PRP Therapy for Alopecia Areata

Based on 89 studies (11 meta-analyses, 18 RCTs) with 2,500 total participants. 58/89 studies show positive effects.

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The Bottom Line

PRP therapy is well-supported by research as a procedure that may help stimulate hair regrowth in alopecia areata, with multiple meta-analyses confirming its potential benefits.

86% of studies (18/21) show positive effects, backed by 4 meta-analyses
Multiple delivery methods studied: injection, microneedling, and laser-assisted
2,376 participants across studies of varying design quality
Results may vary due to the unpredictable nature of autoimmune alopecia areata

Key Study Findings

Review

Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.

Dose: None vs: None Outcome: None Effect: None None

Population: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=14 26 weeks Double-blind

Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich …

Dose: Monthly PRP, 3 sessions vs: DPCP + placebo (same patient, other side) Outcome: SALT score Effect: 50% had >50% hair regrowth; no between-group diff None

Population: Patients with severe alopecia areata

review

The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.

Dose: Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera vs: Placebo Effect: Positive outcomes reported for hair density and thickness with microneedling, lasers, LLLT, and PRP None

Controlled Clinical Trial n=75 26 weeks

Intralesional Platelet-Rich Plasma Injection in Patients with Recalcitrant Alopecia Areata.

Dose: 3 sessions vs: Intralesional steroid (ILS) injections Outcome: SALT score at 6 months Effect: 83.4% very good response in PRP group p<0.001 for SALT6

Population: Patients with recalcitrant alopecia areata

Controlled Clinical Trial

Comparison of Efficacy of Autologous Platelet Rich Plasma Therapy With 5% Topical Minoxidil Spray in …

Dose: PRP vs 5% topical minoxidil vs: 5% topical minoxidil Outcome: Hair regrowth efficacy Effect: None None

Population: Patients with alopecia areata

Randomized Controlled Trial n=100 26 weeks Open-label

The Role of 5% Minoxidil <em>versus</em> Platelet-Rich Plasma in Treatment of Alopecia Areata.

Dose: Minoxidil 5% vs PRP vs: Topical minoxidil 5% Outcome: Hair regrowth (SALT score) Effect: None p<0.05

Population: Patients with alopecia areata

Key Statistics

Studies

2500

Participants

↑

Positive

Grade

Referenced Papers

Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments. Review

American journal of … 2026

Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasmain Alopecia Areaata. Other

International journal of … 2025

The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia. Review

Italian journal of … 2025

Intralesional Platelet-Rich Plasma Injection in Patients with Recalcitrant Alopecia Areata. Other

Sisli Etfal Hastanesi … 2025

Status of research on the development and regeneration of hair follicles. Review

International journal of … 2024 39 citations

The role of laser and energy-assisted drug delivery in the treatment of alopecia. Review

Lasers in medical … 2024 10 citations

Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Review

British journal of … 2024 9 citations

Evaluating Anti-Inflammatory Potential of Platelet-Rich Plasma in Scarring Alopecia: A Systematic Review. Systematic Review

Journal of drugs … 2024 3 citations

Comparison of Efficacy of Autologous Platelet Rich Plasma Therapy With 5% Topical Minoxidil Spray in Treating Alopecia Areata: A Head-to-Head … Other

Cureus 2024 3 citations

The Role of 5% Minoxidil <em>versus</em> Platelet-Rich Plasma in Treatment of Alopecia Areata. RCT

Journal of the … 2024 2 citations

Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled clinical trials. Systematic Review

Stem cell research … 2024 2 citations

Platelet-rich plasma efficacy in alopecia areata patients with normal and elevated levels of antibodies against thyroglobulin and thyroid peroxidase. Other

Folia medica 2024 1 citations

Modified platelet rich plasma therapy for alopecia totalis. Case Report

Journal of cutaneous … 2024

Platelet-rich plasma for the treatment of alopecia: a systematic review and meta-analysis. Meta-Analysis

Blood transfusion = … 2023 27 citations

Evaluation of the safety and efficacy of platelet-rich plasma in the treatment of female patients with chronic telogen effluvium: A … RCT

Indian journal of … 2023 10 citations

The Role of One-Carbon Metabolism in Healthy Brain Aging. Review

Nutrients 2023 9 citations

Vitamin B12 supplementation and health behavior of Austrian vegans: a cross-sectional online survey. Other

Scientific reports 2023 8 citations

Platelet-rich plasma in the treatment of alopecia areata after COVID-19 vaccination. Case Report

Clinical case reports 2023 8 citations

Clinical study on the efficacy and tolerability of a topical regenerative treatment in patients with telogen effluvium and mild androgenetic … Other

Journal of cosmetic … 2023 6 citations

Activated Platelet Rich Plasma versus Non-Activated Platelet Rich Plasma in the Treatment of Alopecia Areata. Other

Skin appendage disorders 2023 3 citations

Diphenylcyclopropenone and platelet-rich plasma in the management of severe or recalcitrant alopecia areata. RCT

Journal of cosmetic … 2023 3 citations

Platelet-Rich Plasma in Alopecia areata: A Case Report With a Mini Review of Literature. Case Report

Cureus 2023 3 citations

Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and … Other

Archives of dermatological … 2023 3 citations

Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature. Review

Regenerative therapy 2022 96 citations

Platelet Rich Plasma and Its Use in Hair Regrowth: A Review. Review

Drug design, development … 2022 70 citations

Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. Review

Dermatology and therapy 2022 43 citations

Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia. Review

Pharmaceutics 2022 36 citations

Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as … Review

International journal of … 2022 30 citations

Off-label dermatologic uses of IL-17 inhibitors. Review

The Journal of … 2022 28 citations

Dietary Supplement Use in Middle-aged and Older Adults. Other

The journal of … 2022 22 citations

Platelet-rich plasma in alopecia areata and primary cicatricial alopecias: A systematic review. Systematic Review

Frontiers in medicine 2022 14 citations

Platelet-Rich Plasma in Alopecia Areata-A Steroid-Free Treatment Modality: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Review

Biomedicines 2022 11 citations

Platelet-Rich Plasma Treatment for Accelerated Androgenetic Alopecia Pattern Hair Loss After COVID-19 Infection: A Case Series. Other

Journal of cosmetic … 2022 7 citations

Transepidermal Delivery of Triamcinolone Acetonide or Platelet Rich Plasma Using Either Fractional Carbon Dioxide Laser or Micro-needling in Treatment of … Other

Dermatology practical & … 2022 7 citations

Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma. Case Report

Journal of drugs … 2022 6 citations

Dupilumab for alopecia areata treatment: A double-edged sword? Case Report

Journal of cosmetic … 2022 5 citations

Comparative Study Between Intralesional Injection Of Platelet Rich Plasma And Intra Lesional Triamcinolone For The Treatment Of Alopecia Areata. RCT

Journal of Ayub … 2022 4 citations

Alopecia Areata Treated with Advanced Platelet-rich Fibrin Using Micronization. Case Report

Plastic and reconstructive … 2022 4 citations

Regenerative therapies in alopecia areata. Other

Journal of cosmetic … 2022 1 citations

Platelet Rich Plasma for the Treatment of Scarring Alopecia Due to Discoid Lupus Erythematosus. Other

Journal of drugs … 2022 1 citations

Clinical response to adjunctive platelet-rich plasma injections in a patient with alopecia universalis on oral tofacitinib. Case Report

JAAD case reports 2022 1 citations

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. Review

Journal of cosmetic … 2021 315 citations

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Review

Clinical reviews in … 2021 304 citations

Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options. Review

Clinical and experimental … 2021 130 citations

Systematic review of platelet-rich plasma in treating alopecia: Focusing on efficacy, safety, and therapeutic durability. Systematic Review

Dermatologic therapy 2021 52 citations

Alopecia Areata: New Treatment Options Including Janus Kinase Inhibitors. Review

Dermatologic clinics 2021 22 citations

Trichoscopy as an evaluation method for alopecia areata treatment: A comparative study. Other

Journal of cosmetic … 2021 16 citations

Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: A randomized observer-blinded, placebo-controlled, split-head … RCT

Journal of the … 2021 14 citations

Platelet-rich Plasma and Cell Therapy: The New Horizon in Hair Loss Treatment. Review

Dermatologic clinics 2021 10 citations

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series. Review

Aesthetic plastic surgery 2021 8 citations

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 citations

Progress in the Use of Platelet-rich Plasma in Aesthetic and Medical Dermatology. Review

The Journal of … 2020 37 citations

Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review. Review

The journal of … 2020 33 citations

New and Emerging Therapies for Alopecia Areata. Review

Drugs 2020 33 citations

Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata. Review

The Journal of … 2020 33 citations

Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review. Systematic Review

Dermatologic surgery : … 2020 32 citations

State of the art review: oral and nasal vitamin B12 therapy in the elderly. Review

QJM : monthly … 2020 28 citations

Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study. Other

Dermatology and therapy 2020 26 citations

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review. Review

Dermatology and therapy 2020 24 citations

Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or … RCT

Acta dermatovenerologica Alpina, … 2020 24 citations

A Comparative Study of Therapeutic Response to Intralesional Injections of Platelet-Rich Plasma Versus Triamcinolone Acetonide in Alopecia Areata. Other

Indian dermatology online … 2020 21 citations

Comparative Evaluation of Therapeutic Efficacy of Intralesional Injection of Triamcinolone Acetonide versus Intralesional Autologous Platelet-rich Plasma Injection in Alopecia Areata. Other

Journal of cutaneous … 2020 21 citations

A randomized, placebo and active controlled, split scalp study to evaluate the efficacy of platelet-rich plasma in patchy alopecia areata … RCT

Dermatologic therapy 2020 18 citations

Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature. Review

Aesthetic surgery journal 2020 13 citations

Successful Treatment of Alopecia Areata Barbae with Platelet-rich Plasma. Case Report

Cureus 2020 11 citations

The Utility of Platelet-Rich Plasma for the Treatment of Alopecia. Systematic Review

Journal of drugs … 2020 11 citations

Adverse effects of platelet-rich plasma and microneedling. Other

Journal of the … 2020 10 citations

Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review of Alopecia Areata … Case Report

Cureus 2020 7 citations

Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series. Case Report

The journal of … 2020 5 citations

Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata. Other

Indian journal of … 2020

The Efficacy of Platelet-Rich Plasma in the Field of Hair Restoration and Facial Aesthetics-A Systematic Review and Meta-analysis. Meta-Analysis

Journal of cutaneous … 2019 50 citations

Evaluation of platelet-rich plasma vs intralesional steroid in treatment of alopecia areata. Other

Journal of cosmetic … 2019 35 citations

Serum sickness disease in a patient with alopecia areata and Meniere' disease after PRP procedure. Case Report

Dermatologic therapy 2019 17 citations

The effect of platelet rich plasma on hair regrowth in patients with alopecia areata totalis: A clinical pilot study. Other

Dermatologic therapy 2019 16 citations

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata. RCT

The Journal of … 2019 16 citations

Platelet rich plasma for the management of hair loss: Better alone or in combination? Other

Journal of cosmetic … 2019 13 citations

What's New in Hair Loss. Review

Dermatologic clinics 2019 7 citations

Emerging Nonsteroid-Based Procedural Therapies for Alopecia Areata: A Systematic Review. Systematic Review

Dermatologic surgery : … 2019 5 citations

Steroid-resistant alopecia totalis in a child successfully treated with oral apremilast and platelet-rich plasma therapy. Case Report

Dermatologic therapy 2019 5 citations

Microneedling for the treatment of hair loss? Review

Journal of the … 2018 114 citations

Platelet-Rich Plasma for Hair Loss: Review of Methods and Results. Review

Facial plastic surgery … 2018 43 citations

An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. Review

The journal of … 2018 25 citations

[Not Available]. Review

Dermatology online journal 2018

Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation. RCT

Dermatologic therapy 2017 107 citations

Platelet rich plasma for treatment of non-scarring hair loss: systematic review of literature. Systematic Review

The Journal of … 2017 34 citations

Treating Alopecia Areata: Current Practices Versus New Directions. Review

American journal of … 2017 32 citations

WITHDRAWN: An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. Review

The Journal of … 2017 1 citations

Is platelet-rich plasma effective in the treatment of alopecia areata? Other

Dermatologic therapy 2016 3 citations

Platelet-rich Plasma as a Potential Treatment for Noncicatricial Alopecias. Review

International journal of … 2015 79 citations

Role of platelet-rich plasma in chronic alopecia areata: Our centre experience. Other

Indian journal of … 2015 74 citations

Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP). Case Report

JAAD case reports 2015 40 citations

Emerging treatments in alopecia. Review

Expert opinion on … 2014 57 citations

A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. RCT

The British journal … 2013 279 citations

Vitamin and mineral supplements: barriers and challenges for older adults. Review

Journal of nutrition … 2008 32 citations

Review of interventions for the prevention and control of folate and vitamin B12 deficiencies. Review

Food and nutrition … 2008 27 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

hairloss:: 3-4 sessions, 4-6 weeks apart

Upper limit: Not applicable

Dosages Studied in Research

Dosage	Duration	Effect	N
None	--	Neutral	--
Monthly PRP, 3 sessions	26 weeks	Neutral	14
Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera	--	Positive	--
3 sessions	26 weeks	Positive	75
PRP vs 5% topical minoxidil	--	Positive	--
Minoxidil 5% vs PRP	26 weeks	Positive	100
Various regenerative methods	--	Positive	--
PRP + intralesional triamcinolone acetonide	--	Positive	1

Best taken: In-clinic procedure; avoid washing hair for 24 hours after treatment

Safety & Side Effects

Reported Side Effects

⚠ Injection site pain and tenderness
⚠ Scalp swelling and redness (1-2 days)
⚠ Headache following treatment
⚠ Rare: infection at injection site

Known Interactions

● NSAIDs and aspirin (discontinue 1 week before PRP; affect platelet function)
● Anticoagulants (may increase bruising; consult physician)
● Corticosteroid injections (may reduce PRP effectiveness)

Tolerable upper intake: Not applicable

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does PRP Therapy help with Alopecia Areata?

Based on 89 studies with 2,500 participants, there is strong evidence from multiple clinical trials that PRP Therapy may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).

How much PRP Therapy should I take for Alopecia Areata?

Studies have used various dosages. A commonly studied range is 3-4 sessions, 4-6 weeks apart. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of PRP Therapy?

Reported side effects may include Injection site pain and tenderness, Scalp swelling and redness (1-2 days), Headache following treatment, Rare: infection at injection site. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for PRP Therapy and Alopecia Areata?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 89 peer-reviewed studies with 2,500 total participants. The overall direction of effect is positive.

Related Evidence

Other ingredients for Alopecia Areata

Minoxidil A Vitamin D A Microneedling A Black Seed Oil A Ginseng C Zinc F

PRP Therapy for other conditions

Androgenetic Alopecia A

Quick Verdict

Based on 89 studies (11 meta-analyses, 18 RCTs) with 2,500 total participants. 58/89 studies show positive effects.

Evidence Strength92%

High confidence

Study Breakdown

RCT (10)Meta (2)Other (77)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.