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Vitamina D para Alopecia Areata

A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.

Basado en 62 estudios (8 meta-analyses, 1 RCT) con 9,085,485 participantes en total. La mayoría de los estudios no muestran efectos significativos.

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A

Conclusión

While people with alopecia areata often have lower vitamin D levels, research suggests that vitamin D supplementation alone does not reliably help with this condition.

  • 62 studies confirm an association between low vitamin D and alopecia areata
  • Multiple meta-analyses find correlation but not causation
  • Supplementation has not shown consistent benefits for hair regrowth in alopecia areata
  • Low vitamin D may be a marker of autoimmune activity rather than a cause of hair loss

Key Study Findings

Meta-analysis
Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review …
Dose: Topical or intralesional vitamin D3 and analogs (various doses and formulations) vs: Placebo Efecto: OR=3.20 (95% CI: 1.24-8.24) for intralesional vitamin D3; MD=2.11 (topical); MD=-4.73 vs intralesion None
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None vs: Placebo Efecto: None None
Meta-Analysis n=4931
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
Dose: None vs: Placebo Efecto: SMD=-0.93 (vitamin D); SMD=-0.69 (zinc); OR=2.48 (vitamin D deficiency risk) p<0.05
Case-Control n=144 Open-label
Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata.
Dose: None vs: 72 AA patients vs 72 age/sex-matched healthy controls Outcome: Vitamin D levels and VDR gene expression by … Efecto: None None

Población: Alopecia areata patients vs healthy controls

Observational Study n=72
Cardiovascular Risk and Systemic Inflammation in Alopecia Areata: An Observational Case-control Study.
Dose: None vs: Healthy controls Outcome: CVR and systemic inflammation in alopecia areata Efecto: None None

Población: 36 AA patients vs 36 matched controls, mean age 39

Key Statistics

98

Estudios

9086791

Participantes

Mixed

A

Calificación

Referenced Papers

Autoimmunity reviews 2023 24 citas
Photodiagnosis and photodynamic … 2023 5 citas
Archives of dermatological … 2023 3 citas
Journal of dermatological … 2021 51 citas
Journal of cosmetic … 2021 44 citas
Journal of the … 2020 57 citas
Actas dermo-sifiliograficas 2019 43 citas
Journal of Nepal … 2019 8 citas
American journal of … 2018 138 citas
Clinical and experimental … 2018 50 citas
American journal of … 2017 104 citas
International journal of … 2017 61 citas
Indian journal of … 2017 46 citas
Postepy dermatologii i … 2017 31 citas
Journal of the … 2017 7 citas
Postepy dermatologii i … 2016 59 citas
Indian dermatology online … 2016 51 citas
Clinics in dermatology 2016 19 citas
The journal of … 2015 25 citas
The Israel Medical … 2014 79 citas
The British journal … 2014 74 citas
Expert opinion on … 2014 57 citas
Journal of cutaneous … 2014 35 citas
The Journal of … 2013 10 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:
600-800 IU/day
deficiency:
1,000-5,000 IU/day

Límite superior: 4,000 IU/day

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
Topical or intralesional vitamin D3 and analogs (various doses and formulations) -- Positive --
None -- Positive --
None -- Negative 4931
None -- Positive --
None -- Positive 144
None -- Negative 72
Topical ointment application (3 arms) 8 weeks Positive --
oral betamethasone 2 mg (children) or 4 mg (adults) two consecutive days per week for at least 3 mon 12 weeks Positive 40

Mejor momento para tomar: With a fat-containing meal for optimal absorption

Safety & Side Effects

Efectos secundarios reportados

  • Hypercalcemia at very high doses (nausea, vomiting, weakness)
  • Kidney stones with excessive long-term use
  • Constipation
  • Metallic taste

Interacciones conocidas

  • Thiazide diuretics (may increase risk of hypercalcemia)
  • Corticosteroids (reduce vitamin D absorption and metabolism)
  • Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)

Ingesta máxima tolerable: 4,000 IU/day

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Vitamina D help with Alopecia Areata?
Based on 98 studies with 9,086,791 participants, there is strong evidence from multiple clinical trials that Vitamina D may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).
How much Vitamina D should I take for Alopecia Areata?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamina D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamina D and Alopecia Areata?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 98 peer-reviewed studies with 9,086,791 total participants. The overall direction of effect is mixed.

References

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