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Dutasterid für Androgenetische Alopezie

A

Basierend auf 43 Studien (7 meta-analyses, 1 RCT) mit 12,060 Teilnehmern insgesamt. 34/43 Studien zeigen positive Effekte.

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A

Fazit

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

  • 34 out of 43 studies show positive effects across 12,060 participants
  • Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
  • Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
  • Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind
Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …
Dose: 0.2 mg dutasteride daily vs.: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline Wirkung: 21.53 vs 5.96 hair count increase 0.0072

Population: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.
Dose: 3 sessions of dutasteride microinfusion (monthly) vs.: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment Wirkung: None None

Population: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label
Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …
Dose: 4 monthly sessions of SPi + iontophoresis vs.: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … Wirkung: None <0.001 (density, diam, pull)

Population: 10 males + 10 postmenopausal females with resistant AGA

Review
Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.
Dose: Dutasteride (oral, various doses) vs.: Placebo Wirkung: None None
Review
Male and female pattern hair loss.
Dose: None vs.: Placebo Wirkung: None None

Key Statistics

99

Studien

19921

Teilnehmer

Positive

A

Bewertung

Referenced Papers

Journal of cosmetic … 2025 3 Zitierungen
Australian prescriber 2025 2 Zitierungen
Journal of cutaneous … 2025 2 Zitierungen
Journal of clinical … 2025 1 Zitierungen
Annals of dermatology 2025
Dermatology (Basel, Switzerland) 2024 14 Zitierungen
Journal of cosmetic … 2024 11 Zitierungen
Facial plastic surgery … 2024 8 Zitierungen
American journal of … 2023 41 Zitierungen
Dermatology and therapy 2023 23 Zitierungen
Fertility and sterility 2020 94 Zitierungen
Neurobiology of stress 2020 72 Zitierungen
General and comparative … 2020 37 Zitierungen
Facial plastic surgery … 2020 15 Zitierungen
Alternative therapies in … 2020 11 Zitierungen
Archivos espanoles de … 2020 1 Zitierungen
Journal of the … 2019 55 Zitierungen
The aging male … 2019 19 Zitierungen
Assay and drug … 2019 19 Zitierungen
Expert opinion on … 2018 38 Zitierungen
Current clinical pharmacology 2017 62 Zitierungen
International journal of … 2017 45 Zitierungen
Actas dermo-sifiliograficas 2017 17 Zitierungen
The Cochrane database … 2016 18 Zitierungen
Indian journal of … 2016 8 Zitierungen
Current problems in … 2015 8 Zitierungen
Expert opinion on … 2014 57 Zitierungen
Current opinion in … 2014 43 Zitierungen
Dermatologic clinics 2013 78 Zitierungen
Journal of cosmetic … 2013 62 Zitierungen
Facial plastic surgery … 2013 16 Zitierungen
International journal of … 2013
Expert opinion on … 2010 264 Zitierungen
Current opinion in … 2009 54 Zitierungen
Seminars in cutaneous … 2009 4 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

hairloss:
0.5 mg/day (off-label)

Obergrenze: 0.5 mg/day

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Neutral --
0.2 mg dutasteride daily 24 weeks Positive 139
3 sessions of dutasteride microinfusion (monthly) 12 weeks Positive 8
4 monthly sessions of SPi + iontophoresis 8 weeks Positive 20
Dutasteride (oral, various doses) -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --

Beste Einnahmezeit: Once daily at the same time, with or without food; prescription required

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Decreased libido (more common than finasteride)
  • Erectile dysfunction
  • Ejaculation disorders
  • Gynecomastia (breast tissue growth)
  • Very long half-life (~5 weeks) means slow side effect resolution

Bekannte Wechselwirkungen

  • CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
  • May affect PSA levels (reduces by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

Tolerierbare Höchstaufnahmemenge: 0.5 mg/day

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Dutasterid help with Androgenetische Alopezie?
Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that Dutasterid may support Androgenetische Alopezie management. Our evidence grade is A (Strong Evidence).
How much Dutasterid should I take for Androgenetische Alopezie?
Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Dutasterid?
Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Dutasterid and Androgenetische Alopezie?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

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