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Dutasteride لـ الثعلبة الأندروجينية

A

بناءً على 43 دراسة (7 meta-analyses, 1 RCT) بمشاركة 12,060 مشاركًا إجمالاً. 34/43 دراسة تُظهر تأثيرات إيجابية.

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الخلاصة

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

  • 34 out of 43 studies show positive effects across 12,060 participants
  • Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
  • Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
  • Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind
Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …
Dose: 0.2 mg dutasteride daily مقابل: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline التأثير: 21.53 vs 5.96 hair count increase 0.0072

المجتمع المدروس: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.
Dose: 3 sessions of dutasteride microinfusion (monthly) مقابل: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment التأثير: None None

المجتمع المدروس: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label
Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …
Dose: 4 monthly sessions of SPi + iontophoresis مقابل: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … التأثير: None <0.001 (density, diam, pull)

المجتمع المدروس: 10 males + 10 postmenopausal females with resistant AGA

Review
Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.
Dose: Dutasteride (oral, various doses) مقابل: Placebo التأثير: None None
Review
Male and female pattern hair loss.
Dose: None مقابل: Placebo التأثير: None None

Key Statistics

99

الدراسات

19921

المشاركون

Positive

A

التقييم

Referenced Papers

Therapeutic delivery 2025 4 اقتباسات
Journal of cosmetic … 2025 3 اقتباسات
Australian prescriber 2025 2 اقتباسات
Journal of cutaneous … 2025 2 اقتباسات
Journal of clinical … 2025 1 اقتباسات
Annals of dermatology 2025
Biomedicines 2024 17 اقتباسات
Dermatology (Basel, Switzerland) 2024 14 اقتباسات
Journal of cosmetic … 2024 11 اقتباسات
Facial plastic surgery … 2024 8 اقتباسات
Journal of cosmetic … 2024 8 اقتباسات
American journal of … 2023 41 اقتباسات
Dermatology and therapy 2023 23 اقتباسات
Dermatologic surgery : … 2023 2 اقتباسات
Dermatologic therapy 2022 14 اقتباسات
Fertility and sterility 2020 94 اقتباسات
Neurobiology of stress 2020 72 اقتباسات
General and comparative … 2020 37 اقتباسات
Facial plastic surgery … 2020 15 اقتباسات
Alternative therapies in … 2020 11 اقتباسات
Archivos espanoles de … 2020 1 اقتباسات
Journal of the … 2019 95 اقتباسات
Journal of the … 2019 55 اقتباسات
The aging male … 2019 19 اقتباسات
Assay and drug … 2019 19 اقتباسات
Expert opinion on … 2018 38 اقتباسات
Current clinical pharmacology 2017 62 اقتباسات
International journal of … 2017 45 اقتباسات
Actas dermo-sifiliograficas 2017 17 اقتباسات
The Cochrane database … 2016 18 اقتباسات
Indian journal of … 2016 8 اقتباسات
Current problems in … 2015 8 اقتباسات
Expert opinion on … 2014 57 اقتباسات
Current opinion in … 2014 43 اقتباسات
Dermatologic clinics 2013 78 اقتباسات
Journal of cosmetic … 2013 62 اقتباسات
Facial plastic surgery … 2013 16 اقتباسات
International journal of … 2013
Skin therapy letter 2012 100 اقتباسات
Expert opinion on … 2010 264 اقتباسات
Current opinion in … 2009 54 اقتباسات
Seminars in cutaneous … 2009 4 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

hairloss:
0.5 mg/day (off-label)

الحد الأعلى: 0.5 mg/day

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Neutral --
0.2 mg dutasteride daily 24 weeks Positive 139
3 sessions of dutasteride microinfusion (monthly) 12 weeks Positive 8
4 monthly sessions of SPi + iontophoresis 8 weeks Positive 20
Dutasteride (oral, various doses) -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --

أفضل وقت للتناول: Once daily at the same time, with or without food; prescription required

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Decreased libido (more common than finasteride)
  • Erectile dysfunction
  • Ejaculation disorders
  • Gynecomastia (breast tissue growth)
  • Very long half-life (~5 weeks) means slow side effect resolution

التفاعلات المعروفة

  • CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
  • May affect PSA levels (reduces by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

الحد الأقصى المسموح به: 0.5 mg/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Dutasteride help with الثعلبة الأندروجينية?
Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that Dutasteride may support الثعلبة الأندروجينية management. Our evidence grade is A (Strong Evidence).
How much Dutasteride should I take for الثعلبة الأندروجينية?
Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Dutasteride?
Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Dutasteride and الثعلبة الأندروجينية?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.