**Figure 7.** Figure 3 Reversal of CBD-mediated TRPV1 desensitization in DRG neurons. Capsaicin responses without any added drugs (A, bar 1), were similar to responses in the presence of 20 µMol/L forskolin (FSK) (A, bar 2). Capsaicin responses were significantly reduced (51.37 ± 6.5% of control, n=6, **P=0.0043), in the presence of 1 µMol/L CBD (A, bar 3). CBD-mediated desensitization of capsaicin responses was abolished in the presence of 20 µMol/L forskolin (FSK) (bar 4, **P=0.0043, n=5). Similarly, capsaicin responses without added drugs (B, bar 1), were equivalent to those in the presence of 100 nMol/L cyclosporin (CSP) (B, bar 2). Desensitization due to 1 µMol/L CBD (B, bar 3, **P=0.0043), was significantly reversed in the combined presence of CBD and the calcineurin inhibitor cyclosporin (B, bar 4, *P=0.017).

描述

CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.

More Figures from This Paper

Figure 5

Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

chart

Figure 6

Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

chart

Figure 8

Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.

chart

Figure 7

Chart

471 × 712px · 122.9 KB

Source Paper

CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.

Journal of pain research (2020)

PMID: 32982390

DOI: 10.2147/JPR.S258433

Cite This Figure

![Figure 7: CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.](https://pdfs.citedhealth.com/figures/32982390/217.png)

> Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." *Journal of pain research*, 2020. PMID: [32982390](https://pubmed.ncbi.nlm.nih.gov/32982390/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/32982390/217.png" alt="CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons." />
  <figcaption>Figure 7. CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.<br>  Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." <em>Journal of pain research</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32982390/">32982390</a></figcaption>
</figure>

描述

More Figures from This Paper

Figure 7

Source Paper

Cite This Figure

相关证据