Zinc Status in Kurdish Adults With Hair Loss.

Hivi Mahmoud, Payman M Saifdeen, Dhia Al-Timimi, Sedghi A Saeed

Other Cureus 2024 1 trích dẫn

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Study Design

Loại nghiên cứu: cross-sectional study

Can thiệp: Zinc Status in Kurdish Adults With Hair Loss. None
Đối chứng: Placebo
Xu hướng hiệu quả: Neutral
Nguy cơ sai lệch: Moderate

Abstract

BACKGROUND: Zinc is an essential element for hair growth and may act as a strong inhibitor in accelerating follicle regression, besides being an accelerator for the recovery of the hair follicle. This study investigated the status of zinc in Kurdish adults with hair loss and its relation with each of the four types of hair loss. METHODS: We investigated the zinc status of a sample of Kurdish adults with hair loss who attended the Dermatology Outpatient Clinics at Azadi Teaching Hospital in Duhok, Kurdistan Region, Iraq. We included a total of 200 subjects in this study, of which 125 had hair loss with a diagnosis of alopecia areata, female pattern hair loss, male pattern hair loss, and telogen effluvium, and 75 were sex- and age-matched apparently healthy subjects without hair fall as a control group. Serum samples were used to measure zinc by colorimetric technique. RESULTS: In participants with hair loss, we found significantly lower serum zinc levels (p=0.002) compared with the control group. The telogen effluvium group had the lowest mean serum zinc level (p=0.006) and higher odds ratio compared with other hair loss groups (4.61). Overall, severe zinc deficiency was found in 12 (9.6%) subjects with hair loss, whereas none of the controls had severe zinc deficiency. Mild-to-moderate zinc deficiency was observed in 43 (34.4%) subjects with hair loss compared to one (1.3%) in the control group. Conclusions: Our results showed that lower zinc status is linked to hair loss, especially alopecia areata and telogen effluvium in the Kurdish population.

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Tables

Table 1

Characteristics	Patients (n=125), mean±SD	Controls (n=75), mean±SD	p-value*
Age (years)	27.5±10.2	26.0±9.9	0.31
Body mass index (kg/m²)	25.1±5.1	24.2±2.9	0.16
Zinc (µg/dl)	76.3±19.5	85.7±10.9	0.002

Table 2

Variable	Females (n=85), n (%)	Males (n=40), n (%)	p-value
Age (years), mean±SD	27.5±10.2	28.9±9.6	0.46
AA	10 (11.7)	18 (45.0)	0.001*
MPHL	0 (0.0)	16 (40.0)	-
FPHL	22 (25.8)	0 (0.0)	-
TE	53 (62.3)	6 (15.0)	0.001*
Serum zinc level (µg/dl), mean±SD	74.7±16.8	78.7±18.7	0.40

Table 3

Zinc (µg/dl)	AA (n=28), n (%)	MPHL (n=16), n (%)	FPHL (n=22), n (%)	TE (n=59), n (%)	Hair Loss Group total (n=125), n(%)	Control Group total (n=75), n (%)
<50	4 (14.3)	0 (0.0)	0 (0)	7 (11.8)	11 ( 8.8)	0 (0)
50-70	11 (39.3)	8 (50.0)	9 (40.9)	26 (44.1)	54 (43.2)	1 (1.33)
>70	13 (46.4)	8 (50.0)	13 (59.1)	26 (44.1)	60 (48.0)	74 (98.66)

Table 4

Type of hair fall	Patients having zinc <70 ug/dl (n=65), n (%)	Zinc levels (ug/dl), mean + SD	Patients having zinc >70 ug/dln (n=60), (%)	Zinc levels (ug/dl), mean + SD	Unadjusted OR (95%Cl)
AA	13 (20.0)	54.4±11.4	15 (25.0)	83.9±13.3	2.95 (1.27-9.01)
MPHL	6 (9.2)	64.2±5.8	10 (16.7)	88.8±10.4	1.65 (0.71-7.7)
FPHL	4 (6.2)	64.4±4.6	18 (30.0)	76.9±7.5	0.56 (0.24-3.0)
TE	42 (64.6)	48.6±9.4	17 (28.3)	86.6±11.2	4.61 (1.91-9.73)
P-value		0.006*		0.086	0.010*