Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam.

PURPOSE: This study aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) therapy in treating androgenetic alopecia (AGA) in Vietnamese patients. PATIENTS AND METHODS: A prospective, non-controlled clinical study was conducted on 41 patients (17 men and 24 women) diagnosed with AGA. PRP was prepared using a standardized double-spin centrifugation protocol and injected subdermally at affected scalp areas. Patients underwent three PRP sessions at four-week intervals. RESULTS: PRP treatment significantly increased hair density from 40.76 ± 14.26 hairs/cm² at T0 to 66.00 ± 18.00 hairs/cm² at T3 (p < 0.05). The percentage of patients with a positive hair pull test decreased from 75.6% (T0) to 12.2% (T3) (p < 0.05). A moderate positive correlation was observed between platelet concentration and hair density improvement (ρ = 0.455, p < 0.001). Patient satisfaction was high, 97.6% satisfied and very satisfied, and only mild, transient adverse effects were noted. CONCLUSION: PRP is an effective and well-tolerated therapy for AGA, significantly improving hair density and reducing hair shedding.