**Figure 8.** Figure 4 Forskolin-stimulated cAMP is inhibited by CBD. cAMP levels in the presence of vehicle (bar 1), were significantly increased by 1 µMol/L FSK (**P=0.0079, n=5), but similar to those in the presence of 1 µMol/L CBD (bar 3, n.s). Forskolin-stimulated cAMP levels (bar 2), were diminished by CBD (bar 4). cAMP levels in the combined presence of 1 µMol/L FSK and 1 µMol/L CBD were significantly higher than vehicle or CBD alone (*P=0.03, n=5).

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Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.

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Figure 5

Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

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Figure 6

Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

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Figure 7

CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.

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Figure 8

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CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.

Journal of pain research (2020)

PMID: 32982390

DOI: 10.2147/JPR.S258433

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![Figure 8: Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.](https://pdfs.citedhealth.com/figures/32982390/232.png)

> Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." *Journal of pain research*, 2020. PMID: [32982390](https://pubmed.ncbi.nlm.nih.gov/32982390/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/32982390/232.png" alt="Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation." />
  <figcaption>Figure 8. Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.<br>  Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." <em>Journal of pain research</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32982390/">32982390</a></figcaption>
</figure>

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