**Figure 6.** Figure 1. Simpliﬁed cellular one-carbon (1C) metabolism. B-vitamins are pleiotropic molecules, as they are involved in nucleotide synthesis, DNA repair, methylation, and transsulfuration. In this review, we focus on the impact of increasing dietary levels of folic acid, vitamin B12, and choline (red text). A control diet with adequate levels will also be used. Abbreviations: folate receptor, FR.

Description

Simplified overview of cellular one-carbon metabolism pathways, illustrating how B-vitamins (folic acid, vitamin B12, choline) participate in nucleotide synthesis, DNA repair, methylation, and transsulfuration reactions relevant to brain health.

Figure 6

Diagram

630 × 325px · 39,5 Kio

Source Paper

The Role of One-Carbon Metabolism in Healthy Brain Aging.

Nutrients (2023)

PMID: 37764675

DOI: 10.3390/nu15183891

Cite This Figure

![Figure 6: Simplified overview of cellular one-carbon metabolism pathways, illustrating how B-vitamins (folic acid, vitamin B12, choline) participate in nucleotide synthesis, DNA repair, methylation, and transsulfuration reactions relevant to brain health.](https://pdfs.citedhealth.com/figures/37764675/62.png)

> Source: Sapna Virdi et al. "The Role of One-Carbon Metabolism in Healthy Brain Aging.." *Nutrients*, 2023. PMID: [37764675](https://pubmed.ncbi.nlm.nih.gov/37764675/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/37764675/62.png" alt="Simplified overview of cellular one-carbon metabolism pathways, illustrating how B-vitamins (folic acid, vitamin B12, choline) participate in nucleotide synthesis, DNA repair, methylation, and transsulfuration reactions relevant to brain health." />
  <figcaption>Figure 6. Simplified overview of cellular one-carbon metabolism pathways, illustrating how B-vitamins (folic acid, vitamin B12, choline) participate in nucleotide synthesis, DNA repair, methylation, and transsulfuration reactions relevant to brain health.<br>  Source: Sapna Virdi et al. "The Role of One-Carbon Metabolism in Healthy Brain Aging.." <em>Nutrients</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37764675/">37764675</a></figcaption>
</figure>

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