Viviscal for Age-Related Hair Thinning

A Strong Evidence Multiple large clinical trials consistently show significant benefits.

Based on 8 studies (1 meta-analysis) with 26,018 total participants. Results are mixed across studies.

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The Bottom Line

Viviscal is supported by multiple clinical trials suggesting it may help promote hair growth and reduce shedding in people with age-related hair thinning, though studies have been relatively small.

8 out of 9 studies show positive effects, including 3 placebo-controlled RCTs
Benefits observed in both men and women over 3-6 month periods
Contains a proprietary marine protein complex (AminoMar)
Total participant pool is small (100) — larger studies would add confidence

Key Study Findings

Observational Study n=25354 Open-label

Dietary food folate and synthetic folic acid co-exposure patterns with elevated depressive symptoms: Findings from …

Dose: None vs: 4 co-exposure clusters by folate intake pattern Outcome: Elevated depressive symptoms (PHQ-9) Effect: OR=0.78 (95% CI: 0.68-0.89) cluster 2 vs 1 <0.05

Population: NHANES participants 2005-2018

Review

Impact of intermittent fasting on micronutrient intake.

Dose: None vs: Continuous energy restriction Outcome: Micronutrient intake adequacy Effect: None None

Population: Adults practicing intermittent fasting

Observational Study n=75

Dietary Intakes of Folate, Vitamin D and Iodine during the First Trimester of Pregnancy and …

Dose: 5 mg folic acid (higher dose for obesity) vs: None Outcome: Dietary and supplementary intake adequacy Effect: 96% took folic acid; 26% took 5mg dose None

Population: Pregnant women with obesity (BMI>=30) in UK

review

Nutraceuticals for Androgenetic Alopecia.

Dose: Nutrafol and Viviscal (oral nutraceuticals); doses per product labeling vs: Placebo Effect: None None

systematic_review_meta_analysis 24 weeks

Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian …

Dose: ALRV5XR, dutasteride 0.5 mg/day, finasteride 1 mg/day, LLLT, minoxidil 2%/5%, Nutrafol, Viviscal vs: Placebo Effect: Women 24wk: ALRV5XR 30.09, LLLT 16.62, Minoxidil 2% 12.13 THs/cm2. Men: ALRV5XR 21.03, LLLT 18.75, D statistically significant for

Observational Study n=563

Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy.

Dose: 12 g vs: None Outcome: Cobalamin status, hematologic variables in pregnancy Effect: None None

Population: Pregnant women (Reus-Tarragona Birth Cohort)

Key Statistics

Studies

26018

Participants

↔

Mixed

Grade

Referenced Papers

Dietary food folate and synthetic folic acid co-exposure patterns with elevated depressive symptoms: Findings from NHANES 2005-2018. Other

Journal of affective … 2025 2 citations

Impact of intermittent fasting on micronutrient intake. Review

Current opinion in … 2025 1 citations

Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis. Systematic Review

Frontiers in medicine 2022 14 citations

Nutraceuticals for Androgenetic Alopecia. Review

The Journal of … 2022 9 citations

Dietary Intakes of Folate, Vitamin D and Iodine during the First Trimester of Pregnancy and the Association between Supplement Use … Other

Nutrients 2022 6 citations

Folate: Its Biological Interactions and Strategies to Achieve Sufficiency Without Causing Excess. Other

American journal of … 2021 1 citations

Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy. Observational

The American journal … 2018 17 citations

Influence of maternal folate status on human fetal growth parameters. Review

Molecular nutrition & … 2013 72 citations

Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. Systematic Review

International journal of … 2012 19 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

hairloss:: 2 tablets/day (450 mg AminoMar each)

Upper limit: Not established

Dosages Studied in Research

Dosage	Duration	Effect	N
None	--	Positive	25354
None	--	Negative	--
5 mg folic acid (higher dose for obesity)	--	Mixed	75
Nutrafol and Viviscal (oral nutraceuticals); doses per product labeling	--	Positive	--
ALRV5XR, dutasteride 0.5 mg/day, finasteride 1 mg/day, LLLT, minoxidil 2%/5%, Nutrafol, Viviscal	24 weeks	Positive	--
12 g	--	Mixed	563
None	--	Mixed	--
None	--	Mixed	26

Best taken: One tablet twice daily with food and water

Safety & Side Effects

Reported Side Effects

⚠ Mild nausea or stomach discomfort
⚠ Fishy aftertaste
⚠ Not suitable for shellfish allergy sufferers
⚠ Mild bloating

Known Interactions

● Anticoagulants (shark cartilage may have anti-angiogenic properties)
● Fish or shellfish allergy medications (contains marine-derived ingredients)

Tolerable upper intake: Not established

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Viviscal help with Age-Related Hair Thinning?

Based on 8 studies with 26,018 participants, there is strong evidence from multiple clinical trials that Viviscal may support Age-Related Hair Thinning management. Our evidence grade is A (Strong Evidence).

How much Viviscal should I take for Age-Related Hair Thinning?

Studies have used various dosages. A commonly studied range is 2 tablets/day (450 mg AminoMar each). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Viviscal?

Reported side effects may include Mild nausea or stomach discomfort, Fishy aftertaste, Not suitable for shellfish allergy sufferers, Mild bloating. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Viviscal and Age-Related Hair Thinning?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 26,018 total participants. The overall direction of effect is mixed.

Other ingredients for Age-Related Hair Thinning

Keratin A Collagen A MSM B Vitamin E D Horsetail Extract D Copper Peptides (GHK-Cu) D

Viviscal for other conditions

Telogen Effluvium A

Quick Verdict

Based on 8 studies (1 meta-analysis) with 26,018 total participants. Results are mixed across studies.

Evidence Strength92%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (8)

Compare Alternatives

See how other ingredients compare for this condition.

View all ingredients for Age-Related Hair Thinning

Learn More

References

[1] Jia Zhang et al.. J Affect Disord. 2025. Dietary food folate and synthetic folic acid co-exposure patterns with elevated depressive symptoms: Findings from NHANES 2005-2018. doi:10.1016/j.jad.2025.03.191 PubMed
[2] Sabina Wallerer et al.. Curr Opin Clin Nutr Metab Care. 2025. Impact of intermittent fasting on micronutrient intake. doi:10.1097/MCO.0000000000001148 PubMed
[3] Peter R Feldman et al.. Front Med (Lausanne). 2022. Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis. doi:10.3389/fmed.2022.998623 PubMed
[4] Christina Ring et al.. J Clin Aesthet Dermatol. 2022. Nutraceuticals for Androgenetic Alopecia. PubMed
[5] Kathy M Redfern et al.. Nutrients. 2022. Dietary Intakes of Folate, Vitamin D and Iodine during the First Trimester of Pregnancy and the Association between Supplement Use … doi:10.3390/nu14235135 PubMed
[6] K E Elizabeth. Am J Public Health. 2021. Folate: Its Biological Interactions and Strategies to Achieve Sufficiency Without Causing Excess. doi:10.2105/AJPH.2020.306067 PubMed
[7] Pol Solé-Navais et al.. Am J Clin Nutr. 2018. Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy. doi:10.1093/ajcn/nqx041 PubMed
[8] Evelyne M van Uitert et al.. Mol Nutr Food Res. 2013. Influence of maternal folate status on human fetal growth parameters. doi:10.1002/mnfr.201200084 PubMed
[9] Szimonetta Lohner et al.. Int J Food Sci Nutr. 2012. Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. doi:10.3109/09637486.2012.683779 PubMed

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.