Black Seed Oil for Telogen Effluvium
A Strong Evidence Multiple large clinical trials consistently show significant benefits.Based on 25 studies (1 meta-analysis, 5 RCTs) with 1,327 total participants. Results are mixed across studies.
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A
The Bottom Line
Black seed oil is associated with strong overall evidence for supporting hair health, and may help with telogen effluvium through its anti-inflammatory properties, though more condition-specific studies would strengthen the case.
- Strong evidence base with 24 out of 25 studies showing positive effects
- Anti-inflammatory and antioxidant properties may support the hair growth cycle
- Much of the evidence comes from general thymoquinone research rather than telogen effluvium-specific trials
- Available in both oral and topical forms for hair support
Key Study Findings
Other
Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …
Dose: 80 mg/kg
vs: None
Outcome: Body weight
Effect: None
p < 0.05
Population: Rat model
Systematic Review
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Dose: Zinc, glutamine, other supplements
vs: Standard care
Outcome: Dysgeusia reduction in chemo patients
Effect: None
None
Population: Chemotherapy patients with dysgeusia
Other
50 weeks
Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …
Dose: 160 mg/kg
vs: Control
Outcome: None
Effect: None
P < 0.05
Population: None
Observational Study
Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.
Dose: 1%
vs: None
Outcome: vitamin B12 status
Effect: None
None
Population: None
Other
Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …
Dose: None
vs: None
Outcome: COVID-19-related diarrhea management
Effect: None
None
Population: COVID-19 patients with diarrhea
randomized controlled animal experiment
n=80
16 weeks
Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …
Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both
vs: Placebo
Effect: None
None
Key Statistics
25
Studies
1327
Participants
↔
Mixed
A
Grade
Referenced Papers
The veterinary quarterly
2024
15 citations
Animal science journal …
2024
3 citations
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Systematic Review
Clinical nutrition ESPEN
2024
Roczniki Panstwowego Zakladu …
2023
5 citations
Veterinary medicine and …
2022
7 citations
Nutrition reviews
2022
3 citations
Journal of dairy …
2020
58 citations
Biological trace element …
2017
35 citations
Zhongguo dang dai …
2016
9 citations
Endocrine, metabolic & …
2015
171 citations
British poultry science
2015
98 citations
Biological trace element …
2015
46 citations
Journal of burn …
2012
16 citations
Biological trace element …
2012
Journal of medicinal …
2011
29 citations
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 citations
Arthritis research & …
2010
17 citations
Current opinion in …
2009
66 citations
European journal of …
2009
24 citations
Molecular biology reports
2007
16 citations
Indian journal of …
2006
25 citations
Pharmacology & therapeutics
2005
199 citations
Metal ions in …
2004
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 citations
Contraception, fertilite, sexualite …
1999
11 citations
Cancer detection and …
1998
22 citations
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- hairloss:
- 1-2 tsp/day or topical application
Upper limit: Not established
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| 80 mg/kg | -- | Neutral | -- |
| Zinc, glutamine, other supplements | -- | Positive | -- |
| 160 mg/kg | 50 weeks | Positive | -- |
| 1% | -- | Mixed | -- |
| None | -- | Positive | -- |
| black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both | 16 weeks | Positive | 80 |
| 104 mg | -- | Positive | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
Best taken: Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing
Safety & Side Effects
Reported Side Effects
- ⚠ Contact dermatitis when applied topically
- ⚠ Gastrointestinal discomfort
- ⚠ May lower blood sugar levels
- ⚠ Possible allergic reactions
Known Interactions
- ● Anticoagulants (may potentiate blood-thinning effects)
- ● Diabetes medications (may enhance hypoglycemic effects)
- ● Immunosuppressants (thymoquinone may stimulate immune activity)
Tolerable upper intake: Not established
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Black Seed Oil help with Telogen Effluvium?
Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that Black Seed Oil may support Telogen Effluvium management. Our evidence grade is A (Strong Evidence).
How much Black Seed Oil should I take for Telogen Effluvium?
Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Black Seed Oil?
Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Black Seed Oil and Telogen Effluvium?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.
Related Evidence
Other ingredients for Telogen Effluvium
Black Seed Oil for other conditions
References
- [1] Muhammad Ishtiaq Khan et al.. Vet Q. 2024. Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and intestinal microarchitecture in broilers. doi:10.1080/01652176.2023.2298491 PubMed
- [2] Ali Afshar Bakeshlo et al.. Anim Sci J. 2024. Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity traits in laying hens. doi:10.1111/asj.13996 PubMed
- [3] Beatrice Mazzoleni et al.. Clin Nutr ESPEN. 2024. Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review. doi:10.1016/j.clnesp.2024.05.026 PubMed
- [4] Radek Latal et al.. Rocz Panstw Zakl Hig. 2023. Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans. doi:10.32394/rpzh.2023.0259 PubMed
- [5] Afrina Mustari et al.. Vet Med Sci. 2022. Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice. doi:10.1002/vms3.708 PubMed
- [6] Heitor O Santos. Nutr Rev. 2022. Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen. doi:10.1093/nutrit/nuab054 PubMed
- [7] M N Chang et al.. J Dairy Sci. 2020. Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … doi:10.3168/jds.2019-17610 PubMed
- [8] Hassan Sadri et al.. Biol Trace Elem Res. 2017. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. doi:10.1007/s12011-017-1014-2 PubMed
- [9] Chao-Xiong Jiang et al.. Zhongguo Dang Dai Er Ke Za Zhi. 2016. [Therapeutic effects of zinc supplement as adjunctive therapy in infants and young children with rotavirus enteritis]. doi:10.7499/j.issn.1008-8830.2016.09.008 PubMed
- [10] Roxana Valdés-Ramos et al.. Endocr Metab Immune Disord Drug Targets. 2015. Vitamins and type 2 diabetes mellitus. doi:10.2174/1871530314666141111103217 PubMed
- [11] V Mohammadi et al.. Br Poult Sci. 2015. Comparative effects of zinc-nano complexes, zinc-sulphate and zinc-methionine on performance in broiler chickens. doi:10.1080/00071668.2015.1064093 PubMed
- [12] Abhay Kumar Singh et al.. Biol Trace Elem Res. 2015. Effects of methionine chelate- or yeast proteinate-based supplement of copper, iron, manganese and zinc on broiler growth performance, their distribution … doi:10.1007/s12011-014-0222-2 PubMed
- [13] Nancy Caldis-Coutris et al.. J Burn Care Res. 2012. Zinc supplementation in burn patients. doi:10.1097/BCR.0b013e31824799a3 PubMed
- [14] Alemu Hunde et al.. Biol Trace Elem Res. 2012. Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. doi:10.1007/s12011-011-9310-8 PubMed
- [15] Ramiro González Matute et al.. J Med Food. 2011. Copper and zinc bioaccumulation and bioavailability of Ganoderma lucidum. doi:10.1089/jmf.2010.0206 PubMed
- [16] S Chang et al.. Eur J Clin Nutr. 2010. Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. doi:10.1038/ejcn.2009.127 PubMed
- [17] Robin Christensen et al.. Arthritis Res Ther. 2010. Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and … doi:10.1186/ar2909 PubMed
- [18] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [19] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [20] Daoxu Sun et al.. Mol Biol Rep. 2007. Regulation of zinc transporters by dietary zinc supplement in breast cancer. doi:10.1007/s11033-007-9082-6 PubMed
- [21] Abdullah H Baqui et al.. Indian J Pediatr. 2006. Zinc supplementation and serum zinc during diarrhea. doi:10.1007/BF02759893 PubMed
- [22] Peter D Zalewski et al.. Pharmacol Ther. 2005. Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. doi:10.1016/j.pharmthera.2004.09.004 PubMed
- [23] Paul W Jones et al.. Met Ions Biol Syst. 2004. The use and role of zinc and its compounds in wound healing. PubMed
- [24] Mark B Salzman et al.. J Pediatr Hematol Oncol. 2002. Excessive oral zinc supplementation. doi:10.1097/00043426-200210000-00020 PubMed
- [25] D Bouglé et al.. Contracept Fertil Sex. 1999. [Iron and zinc supplementation during pregnancy: interactions and requirements]. PubMed
- [26] Y Sheng et al.. Cancer Detect Prev. 1998. DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc. doi:10.1046/j.1525-1500.1998.cdoa37.x PubMed
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.