Ketoconazole لـ الثعلبة الأندروجينية
Aبناءً على 17 دراسة (3 meta-analyses, 2 RCTs) بمشاركة 5,154 مشاركًا إجمالاً. 16/17 دراسة تُظهر تأثيرات إيجابية.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'haircited.com';
const params = 'ingredient\u003Dketoconazole\u0026condition\u003Dandrogenetic\u002Dalopecia';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
الخلاصة
Ketoconazole shampoo has strong evidence supporting its use for androgenetic alopecia, working through both antifungal and anti-androgenic mechanisms, and is recommended as a complement to other hair loss approaches.
- 16 out of 17 studies show positive effects across 5,154 participants
- Works through dual mechanisms: antifungal scalp benefits and local anti-androgenic activity
- Included in clinical guidelines as a complementary approach for pattern hair loss
- Typically used as a 1-2% shampoo applied 2-3 times per week
Key Study Findings
Review
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.
Dose: None
مقابل: None
Outcome: scalp microbiome alterations in androgenetic alopecia
التأثير: None
None
المجتمع المدروس: patients with androgenetic alopecia
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
مقابل: Placebo
التأثير: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
Review
A Canadian Consensus on Androgenetic Alopecia: Approach and Management.
Dose: None
مقابل: Placebo
التأثير: None
None
systematic review
Management of androgenic alopecia: a systematic review of the literature.
Dose: various across 141 included studies
مقابل: Placebo
التأثير: multiple treatments shown to successfully promote hair growth; superiority of multifaceted individua
None
Systematic Review
n=318
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
Dose: None
مقابل: Placebo
التأثير: Increased hair shaft diameter; significant increase in pilary index; clinical improvement by photogr
None
narrative review
Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris.
Dose: varies
مقابل: Placebo
التأثير: None
None
Key Statistics
19
الدراسات
5154
المشاركون
↑
Positive
A
التقييم
Referenced Papers
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.
Review
International journal of …
2026
Journal of cutaneous …
2025
2 اقتباسات
International journal of …
2025
Journal of cosmetic …
2024
11 اقتباسات
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
Systematic Review
Dermatologic therapy
2020
34 اقتباسات
American journal of …
2020
24 اقتباسات
Alternative therapies in …
2020
11 اقتباسات
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Systematic Review
The Journal of …
2019
73 اقتباسات
Pharmaceutics
2019
7 اقتباسات
The Journal of …
2018
69 اقتباسات
Female pattern hair loss.
Review
Current problems in …
2015
8 اقتباسات
Androgenetic alopecia.
Review
Giornale italiano di …
2014
8 اقتباسات
ISRN pharmacology
2014
International journal of …
2013
Skin therapy letter
2012
100 اقتباسات
ISRN dermatology
2011
Clinics in dermatology
2010
Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity.
Other
Journal of dermatological …
2007
39 اقتباسات
Georgian medical news
2007
The Journal of …
2005
24 اقتباسات
Medical hypotheses
2004
21 اقتباسات
The Journal of …
2002
96 اقتباسات
International journal of …
2002
53 اقتباسات
Dermatology (Basel, Switzerland)
1998
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- topical:
- 2% shampoo, 2-3x/week
الحد الأعلى: Topical only for hair loss
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Negative | -- |
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| various across 141 included studies | -- | Positive | -- |
| None | -- | Positive | 318 |
| varies | -- | Positive | -- |
| dutasteride and ketoconazole at pharmacokinetic study doses in rats (not specified in abstract) | -- | Mixed | -- |
| various topical ketoconazole formulations | -- | Positive | 4566 |
أفضل وقت للتناول: Lather on scalp and leave for 3-5 minutes before rinsing; use 2-3 times per week
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Scalp dryness and irritation
- ⚠ Changes in hair texture
- ⚠ Oily or dry scalp (paradoxical)
- ⚠ Contact dermatitis (rare)
التفاعلات المعروفة
- ● Other topical hair treatments (apply at separate times)
- ● Systemic ketoconazole has many interactions but topical has minimal systemic absorption
الحد الأقصى المسموح به: Topical only for hair loss
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Ketoconazole help with الثعلبة الأندروجينية?
Based on 19 studies with 5,154 participants, there is strong evidence from multiple clinical trials that Ketoconazole may support الثعلبة الأندروجينية management. Our evidence grade is A (Strong Evidence).
How much Ketoconazole should I take for الثعلبة الأندروجينية?
Studies have used various dosages. A commonly studied range is 2% shampoo, 2-3x/week. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ketoconazole?
Reported side effects may include Scalp dryness and irritation, Changes in hair texture, Oily or dry scalp (paradoxical), Contact dermatitis (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ketoconazole and الثعلبة الأندروجينية?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 19 peer-reviewed studies with 5,154 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ الثعلبة الأندروجينية
Ketoconazole لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.