Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
Richard P Allen
Review
Sleep medicine clinics
2015
158 次引用
PubMed
DOI
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Study Design
- 研究类型
- Review
- 干预措施
- Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
- 对照组
- Placebo
- 效应方向
- Neutral
- 偏倚风险
- Unclear
Abstract
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.
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