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Figure 1. Effects of single gavage with CBD. Mice were gavaged with 246, 738, or 2460 mg/kg of CBD in sesame oil with tissues harvested at 24 h. (A) Body weight change, (B) liver to body weight ratios, intrahepatic concentrations of (C) total glutathione (
Figure 5. Figure 1. Effects of single gavage with CBD. Mice were gavaged with 246, 738, or 2460 mg/kg of CBD in sesame oil with tissues harvested at 24 h. (A) Body weight change, (B) liver to body weight ratios, intrahepatic concentrations of (C) total glutathione (GSH), (D) reduced glutathione (GSSG), and (E) GSH/GSSG ratio. Data are presented as mean ± SEM (n = 6). * indicates a significant difference as calculated with a One-Way ANOVA and Tukey’s post-hoc test, and # indicates a significant difference as calculated with a Kruskal-Wallis test with a Dunn’s post-hoc test (p < 0.05).

描述

Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.

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Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

Figure 6

Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

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Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

Figure 7

Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

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Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.

Figure 8

Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.

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Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

Figure 9

Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

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Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

Figure 10

Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

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Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.

Figure 11

Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.

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Figure 5

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Source Paper

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Molecules (Basel, Switzerland) (2019)

PMID: 31052254

DOI: 10.3390/molecules24091694

Cite This Figure

![Figure 5: Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.](https://pdfs.citedhealth.com/figures/31052254/75.png)

> Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." *Molecules (Basel, Switzerland)*, 2019. PMID: [31052254](https://pubmed.ncbi.nlm.nih.gov/31052254/)
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  <img src="https://pdfs.citedhealth.com/figures/31052254/75.png" alt="Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses." />
  <figcaption>Figure 5. Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.<br>  Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." <em>Molecules (Basel, Switzerland)</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31052254/">31052254</a></figcaption>
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