Omega-3 脂肪酸用于雄激素性脱发

基于71项研究（8项荟萃分析、9项RCT），共19,624名参与者。58/71项研究显示积极效果。

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结论

Research suggests that omega-3 fatty acids may support hair health as part of a broader nutritional approach to androgenetic alopecia, though they are rarely studied as a standalone solution.

71 studies with nearly 20,000 participants, including 8 meta-analyses
82% of studies show positive effects on hair health
Typically studied as part of multi-nutrient regimens rather than alone
Anti-inflammatory properties may contribute to scalp health and hair growth

Key Study Findings

review

Oral Minoxidil for Alopecia Treatment: Risks, Benefits, and Recommendations.

Dose: Oral minoxidil: women 1.25 mg/day starting dose (range 0.625-5 mg/day); men 2.5 mg/day (range 1.25-5 vs: Placebo 效果: Comparable efficacy to topical minoxidil; hypertrichosis 24%, shedding 16-22%, peripheral edema 2% None

narrative review

Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.

Dose: varies by remedy and study vs: Placebo 效果: None None

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo 效果: None None

review

Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical …

Dose: Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components vs: Placebo 效果: None None

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo 效果: None None

systematic review n=1658 Double-blind

Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.

Dose: various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami vs: Placebo 效果: None None

Key Statistics

研究数量

19624

受试者

↑

Positive

等级

Referenced Papers

Oral Minoxidil for Alopecia Treatment: Risks, Benefits, and Recommendations. Review

American journal of … 2026 1 次引用

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 次引用

Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. Review

Skin appendage disorders 2025 7 次引用

A Scoping Review of Exosome Delivery Applications in Hair Loss. Review

Cureus 2025 7 次引用

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 次引用

Platelet-Rich Plasma Effectiveness in Treating Androgenetic Alopecia: A Comprehensive Evaluation. Review

Cureus 2025 4 次引用

The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis. Review

BJPsych open 2025 2 次引用

First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort. Observational

Human reproduction (Oxford, … 2025 1 次引用

Unmasking Potential Withdrawal Effects of Ashwagandha: A Case Report and Review. Case Report

Cureus 2025 1 次引用

Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. Systematic Review

Frontiers in nutrition 2025

A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled … RCT

Advances in therapy 2025

Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications. Review

Sleep & breathing … 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

The Use of Light-Based Therapies in the Treatment of Alopecia. Review

Journal of cosmetic … 2025

Withania somnifera root extract inhibits MGO-induced skin fibroblast cells dysfunction via ECM-integrin interaction. Other

Journal of ethnopharmacology 2024 10 次引用

Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods. Review

Nutrients 2024 6 次引用

Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A … Other

Clocks & sleep 2024 6 次引用

Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown. Other

Depression and anxiety 2024 1 次引用

Effectiveness of JYNNEOS Vaccine Against Diagnosed Mpox Infection - New York, 2022. Other

MMWR. Morbidity and … 2023 75 次引用

Can Ashwagandha Benefit the Endocrine System?-A Review. Review

International journal of … 2023 43 次引用

Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors. Other

Journal of food … 2023 17 次引用

Over the Counter Supplements for Memory: A Review of Available Evidence. Review

CNS drugs 2023 13 次引用

A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma … Other

Cureus 2023 9 次引用

Clinical study on the efficacy and tolerability of a topical regenerative treatment in patients with telogen effluvium and mild androgenetic … Other

Journal of cosmetic … 2023 6 次引用

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 次引用

Platelet Rich Plasma Combination Therapies for Treatment of Androgenetic Alopecia: A Systematic Review. Review

Journal of cutaneous … 2023 5 次引用

Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment … Meta-Analysis

The Journal of … 2022 40 次引用

Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder. Other

Journal of biomolecular … 2022 25 次引用

Platelet rich plasma application by dermapen microneedling and intradermal point-by-point injection methods, and their comparison with clinical findings and trichoscan … RCT

Dermatologic therapy 2022 19 次引用

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 次引用

Isolation and identification of keratinolytic probiotic Bucillus licheniformis bacteria from the soil below poultry slaughterhouse waste. Other

Brazilian journal of … 2022 4 次引用

Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2. RCT

Ophthalmology 2021 134 次引用

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Review

Current neuropharmacology 2021 129 次引用

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 次引用

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Meta-Analysis

PloS one 2021 64 次引用

Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, … RCT

Journal of ethnopharmacology 2021 58 次引用

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. Review

Planta medica 2021 41 次引用

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. RCT

The journal of … 2021 38 次引用

Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required. Other

Journal of cutaneous … 2021 18 次引用

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 次引用

Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway. Other

Journal of food … 2021 10 次引用

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series. Review

Aesthetic plastic surgery 2021 8 次引用

Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy. Review

European journal of … 2020 87 次引用

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 次引用

Herbal preparations for the treatment of hair loss. Review

Archives of dermatological … 2020 51 次引用

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis. Meta-Analysis

Dermatologic therapy 2020 30 次引用

Efficacy of Brimhana Nasya and Ashwagandha (Withania somnifera (L.) Dunal) root powder in primary insomnia in elderly male: A randomized … Other

Ayu 2020 5 次引用

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Other

Cureus 2019 101 次引用

NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. Observational

Journal of cosmetic … 2019 25 次引用

Non-ablative radio frequency for the treatment of androgenetic alopecia. Other

Acta dermatovenerologica Alpina, … 2019 7 次引用

Insomnia in Elderly Patients: Recommendations for Pharmacological Management. Review

Drugs & aging 2018 131 次引用

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 次引用

Developmental selenium exposure and health risk in daily foodstuffs: A systematic review and meta-analysis. Meta-Analysis

Ecotoxicology and environmental … 2018 77 次引用

Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract … Other

Medicine 2018 14 次引用

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice … Other

Journal of clinical … 2017 1097 次引用

The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. Meta-Analysis

Journal of the … 2017 343 次引用

Platelet-Rich Plasma for Primary Treatment of Partial Ulnar Collateral Ligament Tears: MRI Correlation With Results. Other

Orthopaedic journal of … 2017 72 次引用

A Comparative Study of Microneedling with Platelet-rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia. Other

International journal of … 2017 71 次引用

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. Other

PloS one 2017 57 次引用

Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats. Other

Saudi journal of … 2017 41 次引用

Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Other

Metabolism: clinical and … 2016 29 次引用

Interventions for female pattern hair loss. Meta-Analysis

The Cochrane database … 2016 18 次引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 次引用

Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Review

Biological & pharmaceutical … 2014 110 次引用

Epidemiology of selenium and type 2 diabetes: can we make sense of it? Review

Free radical biology … 2013 208 次引用

Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. Other

BMC biotechnology 2013 118 次引用

[Effectiveness of the treatment plan for androgenetic alopecia]. Other

Georgian medical news 2007

Hepatitis A and B immunization in persons being evaluated for sexually transmitted diseases. Review

The American journal … 2005 25 次引用

Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia. Case Report

The Australasian journal … 2002 20 次引用

[Diffuse hair loss in women]. Other

Therapeutische Umschau. Revue … 2002 4 次引用

Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. Other

Clinical and experimental … 1989 140 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 250-500 mg EPA+DHA/day
hairloss:: 1,000-2,000 mg/day

上限： 3,000 mg/day EPA+DHA

研究中使用的剂量

剂量	持续时间	效果	N
Oral minoxidil: women 1.25 mg/day starting dose (range 0.625-5 mg/day); men 2.5 mg/day (range 1.25-5	--	Positive	--
varies by remedy and study	--	Positive	--
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami	--	Positive	1658
Folic acid supplementation (dose not specified; timing of initiation pre- vs post-conception assesse	--	Positive	480
Ashwagandha extract 600 mg/day (prior to discontinuation)	--	Negative	1

最佳服用时间： With meals containing fat for optimal absorption; split doses if over 1,000 mg

Safety & Side Effects

已报告的副作用

⚠ Fishy aftertaste or burping
⚠ Mild gastrointestinal upset (nausea, diarrhea)
⚠ Possible increased bleeding time at high doses
⚠ Unpleasant body odor at very high doses

已知相互作用

● Anticoagulants (warfarin) and antiplatelet drugs (may increase bleeding risk)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (reduces omega-3 absorption)

可耐受最高摄入量： 3,000 mg/day EPA+DHA

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Omega-3 脂肪酸 help with 雄激素性脱发?

Based on 71 studies with 19,624 participants, there is strong evidence from multiple clinical trials that Omega-3 脂肪酸 may support 雄激素性脱发 management. Our evidence grade is A (Strong Evidence).

How much Omega-3 脂肪酸 should I take for 雄激素性脱发?

Studies have used various dosages. A commonly studied range is 250-500 mg EPA+DHA/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 脂肪酸?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal upset (nausea, diarrhea), Possible increased bleeding time at high doses, Unpleasant body odor at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 脂肪酸 and 雄激素性脱发?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 71 peer-reviewed studies with 19,624 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于雄激素性脱发

米诺地尔（Minoxidil） A 非那雄胺（Finasteride） A PRP 疗法 A 度他雄胺（Dutasteride） A 微针疗法 A 低能量激光疗法（LLLT） A

Omega-3 脂肪酸用于其他健康状况

休止期脱发 B

快速结论

基于71项研究（8项荟萃分析、9项RCT），共19,624名参与者。58/71项研究显示积极效果。

Evidence Strength92%

High confidence

研究分析

RCT (5)Meta (6)Other (60)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于雄激素性脱发

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。

Omega-3 脂肪酸 用于 雄激素性脱发

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结论

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

常用剂量

研究中使用的剂量

Safety & Side Effects

已报告的副作用

已知相互作用

Frequently Asked Questions

Related Evidence

其他成分用于 雄激素性脱发

Omega-3 脂肪酸 用于其他健康状况

Omega-3 脂肪酸用于雄激素性脱发

其他成分用于雄激素性脱发

Omega-3 脂肪酸用于其他健康状况