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Physical Treatments and Therapies for Androgenetic Alopecia.

Siddhi Bianca Camila Lama, Luis Alfonso Pérez-González, Mehmet A Kosoglu, Robert Dennis, Daniel Ortega-Quijano
Review Journal of clinical medicine 2024 10 trích dẫn
PubMed DOI CC-BY PDF
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Loại nghiên cứu
Review
Can thiệp
Physical Treatments and Therapies for Androgenetic Alopecia.
Đối chứng
Placebo
Xu hướng hiệu quả
Neutral
Nguy cơ sai lệch
Unclear

Abstract

Androgenetic alopecia, the most common cause of hair loss affecting both men and women, is typically treated using pharmaceutical options, such as minoxidil and finasteride. While these medications work for many individuals, they are not suitable options for all. To date, the only non-pharmaceutical option that the United States Food and Drug Administration has cleared as a treatment for androgenetic alopecia is low-level laser therapy (LLLT). Numerous clinical trials utilizing LLLT devices of various types are available. However, a myriad of other physical treatments for this form of hair loss have been reported in the literature. This review evaluated the effectiveness of microneedling, pulsed electromagnetic field (PEMF) therapy, low-level laser therapy (LLLT), fractional laser therapy, and nonablative laser therapy for the treatment of androgenetic alopecia (AGA). It also explores the potential of multimodal treatments combining these physical therapies. The majority of evidence in the literature supports LLLT as a physical therapy for androgenetic alopecia. However, other physical treatments, such as nonablative laser treatments, and multimodal approaches, such as PEMF-LLLT, seem to have the potential to be equally or more promising and merit further exploration.

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Tables

Table 1

StudyAGA DiagnosisTreatment RegimenTreatmentSubject Demographics Duration (Weeks)Improvement in Hair Density (Total Hairs/cm2)
Kumar et al., 2018 [31] 2× daily treatmentMinoxidil 5%34 M 27.53 Y (avg.)121.89 ± 8.94
NH III-IV2× daily treatment, as well as 8 sessions: four 1× per week, then four fortnightly sessionsMinoxidil 5% Microneedling34 M 24.56 Y (avg.)1212.82 ± 6.82
Dhurat et al., 2013 [32] 2× daily treatmentMinoxidil 5%44 M 28.6 Y (avg.)1222
NH III-IV2× daily treatment, as well as 1× weekly microneedling (with no minoxidil on day of microneedling)Minoxidil 5% Microneedling50 M 28.6 Y (avg.)1291.4
Choi and Park 2022 [33]NH II+ L I+15 min LLLT and 10 min PEMF17 treatments: 1× per week for 12 weeks, then 1× every 2 weeks for 8 weeks, then 1× in 4 weeksPEMF and LLLT31 M, 9 F 40.18 ± 6.77 Y2324.8 ± 2.65
Sham28 M, 12 F 39.55 ± 7.75 Y236.5 ± 1.85
Bureau et al., 2003 [34]NH I-VII L I-II30 min 3× per weekPEMF and Nutraceutical31 M, 9 F 38.6 ± 8.14 Y2634
Sham and placebo nutraceutical21 M, 8 F 40.6 ± 9.32 Y269
Maddin et al., 1990 [35] 12 min 20 1× per week 4 2× per weekPEMF using Electrotricho-genesis30 M 37.23 ± 5.24 Y123.67 ± 6.72 *
PEMF using Electrotricho-genesis30 M 37.23 ± 5.24 Y247.08 ± 8.59 *
NH III-IV PEMF using Electrotricho-genesis30 M 37.23 ± 5.24 Y3611.87 ± 10.61 *
Sham26 M 37.96 ± 6.76 Y12−1.97 ± 8.79 *
Sham26 M 37.96 ± 6.76 Y241.93 ± 8.3 *
Sham26 M 37.96 ± 6.76 Y365.61 ± 10.25 *
Maddin et al., 1992 [36]NH III-IV12 min 20 1× per week 4 2× per weekPEMF using Electrotricho-genesis14 M 37 ± 2.1 Y2411.66 ± 1.38 *
12 min 26 1× per week 4 2× per weekPEMF using Electrotricho-genesis14 M 37 ± 2.1 Y3017.59 ± 1.98 *
Leavitt et al., 2009 [22]NH IIa-V FS I-IV15 min 3× per weekLLLT using the HairMax LaserComb71 M 47.9 ± 8.7 Y2617.3 ± 11.9 *
Sham39 M 47.9 ± 8.7 Y26−8.9 ± 11.7 *
Kim et al., 2013 [23]NH III-VII L I-III18 min dailyLLLT using the Oaze 3R Helmet15 M and F 43.9 ± 12.2 Y2417.2 ± 12.1
Sham14 M and F 44.5 ± 11.4 Y24−2.1 ± 18.3
Mai-Yi Fan et al., 2018 [25]NH IIa-V LI-4, II-1, II-2 FS I-IV30 min 3× per weekLLLT using the Restore ID-52061 M 37.2 ± 8.3 Y 13 F 37.2 ± 8.3 Y 61 M 37.1 ± 8.1 Y24246 ± 12.5
Sham13 F 37.1 ± 8.1 Y −2 ± 12.6
11 min 3× per weekLLLT using 9-beam HairMax LaserComb42 F 49.3 ± 9.1 Y2620.2 ± 11.2 *
Sham21 F 49.8 ± 7.3 Y262.8 ± 16.5 *
8 min 3× per weekLLLT using 12-beam HairMax LaserComb39 F 48.7 ± 10.2 Y2620.6 ± 11.6 *
Jimenez et al., 2014 [24]NH IIa-V Sham18 F 49.1 ± 8.3 Y263.0 ± 9.3 *
15 min 3× per week LLLT using 7-beam HairMax LaserComb24 M 47.8 ± 9.0 Y2618.4 ± 13.7 *
Sham14 M 40.9 ± 9.5 Y263.0 ± 9.3 *
11 min, 3× per week 8 min, 3× per weekLLLT using 9-beam or HairMax Laser Comb or 12-beam HairMax Laser Comb21 M 45.6 ± 9.3 Y 19 M 47.9 ± 9.6 Y2620.9 ± 13.5 *25.7 ± 17.1 *
Sham21 M 45.9 ± 10.4 Y269.4 ± 12.9 *
Lodi et al., 2021 [37]NH III-VI24 min 2× per weekBlue LLLT20 M 38.55 ±11.68 Y1011 ± 3
Lee et al., 2011 [38]L I-II10 treatments (every fortnight)1550 fractional Er/Glass Laser27 F 41.8 ± 1.96 Y2057 ± 14

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