Comparison between melatonin versus melatonin and photobiomodulation versus photobiomodulation in the treatment of Alopecia X in German Spitz dogs: Clinical, randomized, double-blind, parallel, non-inferiority protocol.
Study Design
- Loại nghiên cứu
- RCT
- Cỡ mẫu
- 60
- Thời gian
- 12 weeks
- Can thiệp
- Comparison between melatonin versus melatonin and photobiomodulation versus photobiomodulation in the treatment of Alopecia X in German Spitz dogs: Clinical, randomized, double-blind, parallel, non-in Melatonin 3 mg/kg; PBM diode laser 660nm, 100mW, 3 J/point, 2 sessions/week
- Đối chứng
- Placebo
- Xu hướng hiệu quả
- Mixed
- Nguy cơ sai lệch
- Low
Abstract
Canine Alopecia X is a non-inflammatory hair loss disorder of unknown etiology that predominantly affects German Spitz dogs. Treatment modalities include hormone and/or melatonin supplementation and low trauma microneedling. Melatonin influences hair growth and pigmentation in several species and presents a low risk of adverse effects when used in dogs with Alopecia X. Photobiomodulation (PBM) is frequently used in human androgenetic alopecia and alopecia areata; despite this, PBM remains unexplored in canine Alopecia X. To address this knowledge gap, sixty dogs of both sexes will be randomly assigned to three groups: (i) melatonin only group (3 mg/Kg, n = 20); (ii) PBM only group (diode laser, wavelength 660nm, 100mw power, with 3 J/point, 2 sessions/week for 3 months, n = 20); (ii) PBM + melatonin group (n = 20). The objective is to determine the potential of PBM alone or in conjunction with melatonin supplementation in promoting hair regrowth (hair density and diameter) by means of dermatoscopy and planimetry over a period of 90 days.
Full Text
Figures
Fig 1
Study design and group allocation for the randomized trial comparing melatonin, melatonin plus photobiomodulation, and photobiomodulation alone for treating Alopecia X in German Spitz dogs.
flowchart
Fig 2
Clinical photographs or hair regrowth scores in German Spitz dogs across the three treatment groups at baseline and follow-up time points.
photograph
Fig 3
Quantitative hair regrowth or dermoscopy outcomes comparing melatonin, combination therapy, and photobiomodulation-only groups in dogs with Alopecia X.
chart
Fig 4
Additional clinical outcome data or photographic documentation from the Alopecia X treatment trial in German Spitz dogs.
photograph
Fig 5
Summary comparison or statistical analysis of treatment responses across the three arms of the canine Alopecia X study.
chartTables
Table 1
| Parameters | |
|---|---|
| Peak wavelength [nm] | 660nm |
| Spectral bandwidth (FWHM) [nm] | 2 |
| Operating mode | Continuous wave |
| Average radiante power [mW] | 100 |
| Polarization | Linearly polarized |
| Irradiance at aperture [mW/cm2] | 5650 |
| Beam profile | Multimode |
| Beam spot size at target [cm2] | 0,0177 |
| Exposure duration per site [s] | 30 |
| Radiant exposure at target [J/cm2] | 169 |
| Radiant energy per site [J] | 3 |
| Application technique | contact with the skin surface, each application point is 1.5 cm away from the other |
| Frequency of treatment sessions | 2x per week, during 13 weeks |
| Number of treatment sessions | 26 |
References
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- Untitled Kirk’s Current Veterinary Therapy XIII Small Animal Practice,, 2000
- The efficacy of subcutaneous slow-release melatonin implants in the prevention of canine flank alopecia recurrence is uncertain: A double-blind, randomized, placebo-controlled study. Vet Dermatol., 2022
- Untitled Dermatologia em pequenos animais, 2011
- Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. Vet Dermatol, 2004
- Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation. Vet Dermatol, 2006
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- Untitled
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