5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety.

Rachita Dhurat, Aseem Sharma, Lidia Rudnicka, George Kroumpouzos, Martin Kassir et al.

Review Dermatologic therapy 2020 60 trích dẫn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'haircited.com'; const params = 'pmid\u003D32279398'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Loại nghiên cứu: Review
Đối tượng nghiên cứu: Androgenetic alopecia patients

Can thiệp: 5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety. None
Đối chứng: None
Kết quả chính: None
Xu hướng hiệu quả: Positive
Nguy cơ sai lệch: Unclear

Abstract

Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

Tóm lược

This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

Used In Evidence Reviews

A Finasteride cho Rụng Tóc Androgen

A Dutasteride cho Rụng Tóc Androgen

5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety.

Embed This Widget

Study Design

Abstract

Tóm lược

Used In Evidence Reviews

Similar Papers

Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.

Androgenetic alopecia: a review.

The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis.

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.

Male androgenetic alopecia.

Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men - short version.