Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group.

Ladan Dastgheib, Zohreh Mostafavi-Pour, Ahmad Adnan Abdorazagh, Zahra Khoshdel, Maryam Sadat Sadati et al.

Other Dermatology research and practice 2014 32 trích dẫn

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Study Design

Loại nghiên cứu: Case-Control
Cỡ mẫu: 43

Can thiệp: Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group. None
Đối chứng: Placebo
Xu hướng hiệu quả: Neutral
Nguy cơ sai lệch: Moderate

Abstract

Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. Materials and Methods. Sixteen female patients with AA (14-40 years old) and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15. Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron (r = 0.504, P = 0.001), zinc (r = 0.684, P = 0.0001), and copper (r = 0.759, P = 0.0001) in patients and controls. Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients.

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Figures

Figure 1

Zinc, copper, and iron concentrations in hair samples from alopecia areata patients compared to healthy controls are presented, indicating altered trace element profiles in affected individuals.

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Figure 2

Serum levels of zinc, copper, and iron in alopecia areata patients versus a normal control group are compared, suggesting potential associations between trace element imbalances and autoimmune hair loss.

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Figure 3

Correlation analysis between hair and serum trace element concentrations in alopecia areata patients is shown, exploring whether systemic mineral status reflects local hair follicle environment changes.

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Tables

Table 1

Parameter		Case (n = 16)	Control (n = 27)	P value
Age (mean ± SD) (years)		26.63 ± 8.53	25.07 ± 5.01	0.515

Disease duration (months)		23.69 ± 41.55

Occupation	Student House wife Employee	5 (31.3) 9 (56.3) 2 (12.5)	13 (48.1) 2 (7.4) 12 (44.4)	0.001

AA	No Yes	9 (56.3)7 (43.8)	27 (100) 0 (0)	0.0001

DM	No Yes	15 (93.8) 1 (6.3)	27 (100) 0 (0)	0.372

TY	No Yes	15 (93.8) 1 (6.3)	26 (96.3) 1 (3.7)	0.611

AU	No Yes	16 (100)0 (0)	27 (100) 0 (0)	1

AA in family	No Yes	13 (81.3) 3 (18.8)	27 (100) 0 (0)	0.045

DM in family	No Yes	12 (75) 4 (25)	20 (74.1) 7 (25.9)	0.621

TY in family	NoYes	13 (81.3) 3 (18.8)	26 (96.3) 1 (3.7)	0.137

AU in family	No Yes	15 (93.8) 1 (6.3)	27 (100) 0 (0)	0.327

Pitting nail	No Yes	15 (93.8) 1 (6.3)	27 (100) 0 (0)	0.327

Table 2

Parameter	Case (n = 16)	Control (n = 27)	P value∗
Serum Fe (µg/dL)	108 ± 36	96.01 ± 33	0.251
Hair Fe (µg/g)	128 ± 18	117.84 ± 22	0.121
Serum Zn (µg/dL)	134 ± 46	136.76 ± 41	0.877
Hair Zn (µg/g)	270 ± 58	279.35 ± 61	0.65
Serum Cu (µg/dL)	143 ± 38	128.32 ± 23	0.12
Hair Cu (µg/g)	52 ± 62	67.59 ± 59	0.441

Table 3

		Zinc (hair)	Iron (hair)	Copper (hair)
Zinc (hair)	Pearson correlation	1	.100	.192
	Sig. (2-tailed)		.517	.211
	N	44	44	44

Iron (hair)	Pearson correlation	.100	1	.177
	Sig. (2-tailed)	.517		.251
	N	44	44	44

Copper (hair)	Pearson correlation	.192	.177	1
	Sig. (2-tailed)	.211	.251
	N	44	44	44

Table 4

		Zinc (plasma)	Iron (plasma)	Copper (plasma)
Zinc (plasma)	Pearson correlation	1	−.319∗	.104
	Sig. (2-tailed)		.042	.516
	N	41	41	41

Iron (plasma)	Pearson correlation	−.319∗	1	.142
	Sig. (2-tailed)	.042		.377
	N	41	41	41

Copper (plasma)	Pearson correlation	.104	.142	1
	Sig. (2-tailed)	.516	.377
	N	41	41	41

References

The pathogenesis of alopecia areata Dermatologic Clinics, 1996
The aetiology and pathogenesis of alopecia areata Journal of Dermatological Science, 1994
Element concentrations in serum, erythrocytes, hair and urine of alopecia patients Acta Dermato-Venereologica, 1986
Assay of trace elements, thyroid gland and blood indices in children with alopecia Trace Elements and Electrolytes, 2004
Alopecia areata: a revision and update Anais Brasileiros de Dermatologia, 2005
Treatment of alopecia areata with zinc sulfate Zeitschrift für Hautkrankheiten, 1980
Zinc in treatment of alopecia areata Przeglad Dermatologiczny, 1978
Zinc as an ambivalent but potent modulator of murine hair growth in vivo—preliminary observations Experimental Dermatology, 2005
Analysis of serum zinc and copper levels in alopecia areata Annals of Dermatology, 1997
Zinc and its status in some dermatological diseases: a statistical assessment Zeitschrift für Hautkrankheiten, 1987
Decreased serum ferritin is associated with alopecia in women Journal of Investigative Dermatology, 2003
Evaluation of serum iron and ferritin levels in alopecia areata Dermatology Online Journal, 2008
The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low serum zinc level Annals of Dermatology, 2009
Trace element levels in alopecia areata Indian Journal of Dermatology, Venereology and Leprology, 2009

Used In Evidence Reviews

F Kẽm cho Alopecia Areata

Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group.

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