Androgens and hair loss.

Adel Alsantali, Jerry Shapiro

Review Current opinion in endocrinology, diabetes, and obesity 2009 54 цитирований

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Тип исследования: Review
Популяция: None

Вмешательство: Androgens and hair loss. None
Препарат сравнения: None
Первичный исход: Androgens and hair loss.
Направление эффекта: Positive
Риск систематической ошибки: Unclear

Abstract

PURPOSE OF REVIEW: Androgenetic alopecia (AGA) or male pattern hair loss is a very common condition that has a significant psychosocial impact for patients. Many advances in the pathogenesis and treatment of AGA have been discovered recently. We discuss the pathogenesis and treatment of AGA. RECENT FINDINGS: Wide genome analysis showed an association of AGA and chromosome 20pll in addition to androgen-receptor gene. Also, a locus on chromosome 3q26 was found to have a linkage with AGA. Dutasteride has been shown to be more effective than finasteride in the treatment of AGA but is not yet a recommended therapy. In an in-vitro study, a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution. SUMMARY: These recent developments in the field of AGA hold some promise and may play a role in the future management.

Кратко

The pathogenesis and treatment of AGA is discussed and a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution.

Used In Evidence Reviews

A Minoxidil для Андрогенетическая алопеция

A Finasteride для Андрогенетическая алопеция

A Dutasteride для Андрогенетическая алопеция

Androgens and hair loss.

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Abstract

Кратко

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