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Fig 5. The structure of human SRD5A2. (A), Spheres represent NADP-DHF adduct. L1-6 are the 6 loops connecting the 7 transmembranes (TM), and the TM portion has 254 amino acid residues. (B), The active site inside the 7 TM channels surrounded by L1, L3, an
Figure 5. Fig 5. The structure of human SRD5A2. (A), Spheres represent NADP-DHF adduct. L1-6 are the 6 loops connecting the 7 transmembranes (TM), and the TM portion has 254 amino acid residues. (B), The active site inside the 7 TM channels surrounded by L1, L3, and L5, with 2 separate pockets for NADP and DHF (shown in red circle). (Adapted from Xiao et al25).

Описание

The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel.

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Figure 3

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diagram
Finasteride's mechanism of inhibition is depicted at the molecular level, showing covalent adduct formation between NADPH and finasteride that prevents further hydride transfer to testosterone.

Figure 4

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diagram

Figure 5

Diagram
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Source Paper

Androgenetic alopecia: An update.

JAAD international (2023)

PMID: 37823040

DOI: 10.1016/j.jdin.2023.07.005

Cite This Figure

![Figure 5: The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel.](https://pdfs.citedhealth.com/figures/37823040/128.png)

> Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." *JAAD international*, 2023. PMID: [37823040](https://pubmed.ncbi.nlm.nih.gov/37823040/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/37823040/128.png" alt="The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel." />
  <figcaption>Figure 5. The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel.<br>  Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." <em>JAAD international</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37823040/">37823040</a></figcaption>
</figure>

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