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Ketoconazole для Андрогенетическая алопеция

A

На основе 17 исследований (3 meta-analyses, 2 RCTs) с участием 5,154 участников. 16/17 исследований показывают положительные эффекты.

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A

Итог

Ketoconazole shampoo has strong evidence supporting its use for androgenetic alopecia, working through both antifungal and anti-androgenic mechanisms, and is recommended as a complement to other hair loss approaches.

  • 16 out of 17 studies show positive effects across 5,154 participants
  • Works through dual mechanisms: antifungal scalp benefits and local anti-androgenic activity
  • Included in clinical guidelines as a complementary approach for pattern hair loss
  • Typically used as a 1-2% shampoo applied 2-3 times per week

Key Study Findings

Review
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.
Dose: None или: None Outcome: scalp microbiome alterations in androgenetic alopecia Эффект: None None

Популяция: patients with androgenetic alopecia

laboratory/in vitro 26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. или: Placebo Эффект: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None
Review
A Canadian Consensus on Androgenetic Alopecia: Approach and Management.
Dose: None или: Placebo Эффект: None None
systematic review
Management of androgenic alopecia: a systematic review of the literature.
Dose: various across 141 included studies или: Placebo Эффект: multiple treatments shown to successfully promote hair growth; superiority of multifaceted individua None
Systematic Review n=318
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
Dose: None или: Placebo Эффект: Increased hair shaft diameter; significant increase in pilary index; clinical improvement by photogr None
narrative review
Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris.
Dose: varies или: Placebo Эффект: None None

Key Statistics

19

Исследования

5154

Участники

Positive

A

Оценка

Referenced Papers

Journal of cutaneous … 2025 2 цитирований
Journal of cosmetic … 2024 11 цитирований
Dermatologic therapy 2020 34 цитирований
American journal of … 2020 24 цитирований
Alternative therapies in … 2020 11 цитирований
Current problems in … 2015 8 цитирований
Giornale italiano di … 2014 8 цитирований
International journal of … 2013
Skin therapy letter 2012 100 цитирований
Journal of dermatological … 2007 39 цитирований
The Journal of … 2005 24 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

topical:
2% shampoo, 2-3x/week

Верхний предел: Topical only for hair loss

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Negative --
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. 26 weeks Positive --
None -- Positive --
various across 141 included studies -- Positive --
None -- Positive 318
varies -- Positive --
dutasteride and ketoconazole at pharmacokinetic study doses in rats (not specified in abstract) -- Mixed --
various topical ketoconazole formulations -- Positive 4566

Лучшее время приёма: Lather on scalp and leave for 3-5 minutes before rinsing; use 2-3 times per week

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Scalp dryness and irritation
  • Changes in hair texture
  • Oily or dry scalp (paradoxical)
  • Contact dermatitis (rare)

Известные взаимодействия

  • Other topical hair treatments (apply at separate times)
  • Systemic ketoconazole has many interactions but topical has minimal systemic absorption

Допустимый верхний уровень потребления: Topical only for hair loss

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Ketoconazole help with Андрогенетическая алопеция?
Based on 19 studies with 5,154 participants, there is strong evidence from multiple clinical trials that Ketoconazole may support Андрогенетическая алопеция management. Our evidence grade is A (Strong Evidence).
How much Ketoconazole should I take for Андрогенетическая алопеция?
Studies have used various dosages. A commonly studied range is 2% shampoo, 2-3x/week. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ketoconazole?
Reported side effects may include Scalp dryness and irritation, Changes in hair texture, Oily or dry scalp (paradoxical), Contact dermatitis (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ketoconazole and Андрогенетическая алопеция?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 19 peer-reviewed studies with 5,154 total participants. The overall direction of effect is positive.

Related Evidence

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.