Descrição
The DHT synthesis pathway via SRD5A2 is diagrammed, showing how 5-alpha reductase converts testosterone to dihydrotestosterone in the presence of NADPH, the key hormonal driver of AGA.
More Figures from This Paper
Figure 2
Classification systems for androgenetic alopecia severity are presented, distinguishing male and female pattern hair loss stages.
diagram
Figure 4
Finasteride's mechanism of inhibition is depicted at the molecular level, showing covalent adduct formation between NADPH and finasteride that prevents further hydride transfer to testosterone.
diagram
Figure 5
The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel.
diagramCite This Figure
 > Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." *JAAD international*, 2023. PMID: [37823040](https://pubmed.ncbi.nlm.nih.gov/37823040/)
<figure> <img src="https://pdfs.citedhealth.com/figures/37823040/113.png" alt="The DHT synthesis pathway via SRD5A2 is diagrammed, showing how 5-alpha reductase converts testosterone to dihydrotestosterone in the presence of NADPH, the key hormonal driver of AGA." /> <figcaption>Figure 3. The DHT synthesis pathway via SRD5A2 is diagrammed, showing how 5-alpha reductase converts testosterone to dihydrotestosterone in the presence of NADPH, the key hormonal driver of AGA.<br> Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." <em>JAAD international</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37823040/">37823040</a></figcaption> </figure>