Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review.
Robert J Dabek,
Daniel S Roh,
Derman Ozdemir,
William G Austen,
Branko Bojovic
Review
Cureus
2019
18 件の引用
PubMed
DOI
CC-BY
PDF
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Study Design
- 研究タイプ
- systematic_review
- 介入
- Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review. fractional laser therapy (6 laser types) or microneedling (2 studies) — with or without topical agen
- 比較対照
- Placebo
- 効果の方向
- Positive
- バイアスリスク
- High
Abstract
Alopecia areata (AA) affects approximately 2.1% of the population, with women being affected more often than men. Current therapies consisting of topical corticosteroids or intralesional injections are often the first choices for treatment, but are limited by unsatisfactory outcomes or risks to patients. Recently, fractional lasers and microneedling, with or without the addition of topical agents, have been examined as treatment options. A literature review was performed to evaluate the efficacy of fractional lasers in the treatment of AA. A total of six fractional lasers and two microneedling studies consisting of small prospective and retrospective studies, and case reports were reviewed. The number of trials and participants are limited, but evidence suggests that fractional lasers and microneedling may be effective therapeutic approaches when coupled with topical agents. Larger studies are required to better understand the effects of these treatment modalities for AA.
Full Text
Tables
Table 1
| Author, year | Resurfacing technique | Additional treatment(s) | Study Design | Laser/needling settings | Number of sessions | Interval | Number of Subjects | Alopecia type | Adverse effects | results |
| Yalici-Armagan et al., 2016 [ | CO2 laser (10600 nm) Nd:YAG* laser (1064 nm) | None | Prospective, split lesion study | 10-45 mJ/cm2, 75-100 spots/cm2 10 J/cm2, 30 millisecond pulse | 3-6 | 2-4 weeks 2-8 weeks | 32 (19 male, 13 female) | Alopecia areata | Pain | No improvement |
| Issa et al., 2016 [ | CO2 laser (10600 nm) | Topical corticosteroid | Prospective study | 60 mJ/spot, 100 spots/cm2, 2 passes | 1-6 | 3 weeks | 5 (1 male, 4 female) | Alopecia areata | Mild burning pain | Improvement in all patients |
| Eckert et al., 2016 [ | Erbium glass laser (1550 nm) | None | Retrospective series | Variable | 2-3 | 3-6 weeks | 5 (2 male, 3 female) | Alopecia areata | Pain | Improvement in all treated lesions |
| Cho et al., 2013 [ | CO2 laser (10600 nm) Erbium glass laser (1550 nm) | Variable | Retrospective series | 30-50 mJ/spot, 150 spots/cm2 6-8 mJ/spot, 300 spots/cm2 | 2-3 | 3-6 weeks | 3 (1 male, 2 female) | Ophiasis | Pain, crusting, scaling, erythema, and edema | 2 of 3 patients demonstrated improvement |
| Tsai, 2011 [ | Erbium glass laser (1550 nm) | Intralesional corticosteroid injection | Split scalp case report | Not reported | 12 | 1 week | 1 male | Alopecia areata | None | Improvement vs steroid alone |
| Yoo et al., 2010 [ | Erbium glass laser (1550 nm) | None | Case report | 10-15 mJ/spot, 300 spots/cm2, 2 passes | 24 | 1 week | 1 male | Alopecia areata | None | Complete regrowth in treated lesions |
| Mysore et al., 2014 [ | Microneedle dermaroller | Topical corticosteroids | Case series | 3 | 3 weeks | 2 males | Alopecia areata | None | Improvement | |
| Yoo et al., 2010 [ | 1 mm microneedle roller | Topical methyl 5-aminolevulinate acid and photodynamic therapy with red light | Split lesion case series | 3 | 4 weeks | 8 (2 male, 6 female) | Alopecia areata | Mild pain, and erythema | No improvement |
References
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