Male androgenetic alopecia.
Gabriel Lazzeri Cortez,
Karime Hassun,
Luciana Ribeiro Patricio Linhares,
Verena Florenço,
Maria Valeria Bussamara Pinheiro
et al.
Review
Anais brasileiros de dermatologia
2025
7 citazioni
PubMed
DOI
CC-BY
PDF
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Study Design
- Tipo di studio
- narrative review
- Intervento
- Male androgenetic alopecia. not specified
- Comparatore
- Placebo
- Direzione dell'effetto
- Positive
- Rischio di bias
- Unclear
Abstract
Male androgenetic alopecia (MAA) is quite common and worsens with age, with a significant impact on quality of life, and is increasingly a reason for consultation with a dermatologist. The etiopathogenesis of MAA is multifactorial and genetic and hormonal influences stand out. MAA starts with the process of follicular miniaturization in diverse phenotypic patterns. The diagnosis of MAA is basically clinical and currently corroborated by well-established trichoscopic findings. Despite this, therapeutic options are limited, especially when one considers medications with a high level of scientific evidence. This review aims to help the general dermatologist towards a better understanding of MAA providing a basis for good individualized and judicious therapeutic decisions.
Full Text
Figures
Fig. 1
Classification or staging system for male androgenetic alopecia, illustrating the progressive patterns of hair loss (Hamilton-Norwood scale or similar).
diagram
Fig. 2
Pathophysiology overview of male androgenetic alopecia, depicting the role of dihydrotestosterone (DHT) and androgen receptor signaling in hair follicle miniaturization.
diagram
Fig. 3
Current treatment algorithm for male androgenetic alopecia, comparing pharmacological (finasteride, minoxidil) and procedural interventions.
diagram
Fig. 4
Clinical photographs or dermoscopic images illustrating different stages or treatment responses in male androgenetic alopecia.
photograph
Fig. 5
Emerging therapeutic approaches for male androgenetic alopecia, including novel molecular targets and regenerative medicine strategies.
diagram
Fig. 6
Summary of evidence-based recommendations for managing male androgenetic alopecia, synthesizing data from clinical trials and systematic reviews.
photographTables
Table 1
| Differential diagnoses |
|---|
| Telogen Effluvium |
| Alopecia Areata |
| Senescent Alopecia |
| Traction alopecia |
| Trichotillomania |
| Frontal Fibrosing Alopecia |
| Lichen Planopilaris |
| Permanent post-CT alopecia |
| Central Centrifugal Cicatricial Alopecia |
| Congenital Triangular Alopecia |
Table 2
| Differences between 5α-reductase inhibitors | ||
|---|---|---|
| Finasteride | Dutasteride | |
| Half-life | 5-8 hours | 3-5 weeks |
| 5-AR Inhibition | Only type 2 | Types 1 and 2 |
| Systemic DHT suppression | ∼71% | >90% |
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