Vitamin D supplementation for patients with alopecia areata: A protocol for systematic review and meta-analysis.
Study Design
- Tipo di studio
- Meta-analysis
- Intervento
- Vitamin D supplementation for patients with alopecia areata: A protocol for systematic review and meta-analysis. None
- Comparatore
- Placebo
- Direzione dell'effetto
- Neutral
- Rischio di bias
- Unclear
Abstract
BACKGROUND: Several studies have reported an association between low Vitamin D (VD) levels and Alopecia areata (AA), and suggested VD preparations as a potential therapy. VD has immunomodulatory function closely associated with a variety of skin diseases, but there is no conclusive evidence to support VD supplementation for patients with AA. Therefore, we will conduct a meta-analysis to collect and evaluate the efficacy and safety of VD supplementation in the treatment of AA. METHODS: We will search the following databases according to the developed strategy: Cochrane Library, PubMed, Web of Science, EMBASE, Scopus, Google scholar for Randomized controlled trials related to VD supplementation for AA. The retrieval time is from the establishment of each database to July 2022. Two reviewers will independently complete the literature search and screening, risk of bias assessment and data extraction. Severity of Alopecia Tool, Alopecia Density and Extent, Lesional area and senstivity (score) will be the primary results. RevMan V.5.3 will be used for data analysis and synthesis. For dichotomous outcomes and the continuous outcomes, we will calculate risk ratio with 95% Confidence intervals and mean differences or standardized mean differences with 95% Confidence intervals respectively. The reporting bias will be investigated using funnel plots, and the asymmetry of the funnel plots will be explained using the Harbord modified test or the Egger's regression test. RESULTS: The results of the study expect to provide a high-quality, evidence-based recommendation on VD supplementation in the treatment of AA for clinicians. CONCLUSIONS: The study will provide scientific and useful evidence for better use of VD supplementation in treating AA.
Full Text
Figures
Tables
Table 1
| Search strategy for The Cochrane Library | |
|---|---|
| #1 | MeSH descriptor: [Vitamin D] explode all trees |
| #2 | MeSH descriptor: [Ergocalciferols] explode all trees |
| #3 | (“Calciferols”):ti,ab,kw OR (“D2, Vitamin”):ti,ab,kw OR (“Vitamin D2”):ti,ab,kw OR (“Ergocalciferol”):ti,ab,kw OR (“Vitamin D2”):ti,ab,kw |
| #4 | #2 OR #3 |
| #5 | MeSH descriptor: [Cholecalciferol] explode all trees |
| #6 | (“(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol”):ti,ab,kw OR (“Calciol”):ti,ab,kw OR (“Vitamin D 3”):ti,ab,kw OR (“Vitamin D3”):ti,ab,kw OR (“Cholecalciferols”):ti,ab,kw |
| #7 | #5 OR #6 |
| #8 | MeSH descriptor:[Calcitriol] explode all trees |
| #9 | (“Sitriol”):ti,ab,kw OR (“Rocaltrol”):ti,ab,kw OR (“1 alpha,25-Dihydroxyvitamin D3”):ti,ab,kw OR (“1,25-Dihydroxyvitamin D3”):ti,ab,kw |
| #10 | (“D3, 1 alpha,25-Dihydroxyvitamin”):ti,ab,kw OR (“1,25 Dihydroxyvitamin D3”):ti,ab,kw OR (“1 alpha,25-Dihydroxycholecalciferol”):ti,ab,kw |
| #11 | (“1 alpha,25 Dihydroxyvitamin D3”):ti,ab,kw OR (“1,25 Dihydroxycholecalciferol”):ti,ab,kw OR (“D3, 1,25-Dihydroxyvitamin”):ti,ab,kw |
| #12 | (“1,25-Dihydroxycholecalciferol”):ti,ab,kw OR (“Bocatriol”):ti,ab,kw OR (“Renatriol”):ti,ab,kw OR (“Calcitriol KyraMed”):ti,ab,kw |
| #13 | (“KyraMed, Calcitriol”):ti,ab,kw OR (“Osteotriol”):ti,ab,kw OR (“Calcijex”):ti,ab,kw OR (“Decostriol”):ti,ab,kw OR (“Tirocal”):ti,ab,kw |
| #14 | (“MC 1288”):ti,ab,kw OR (“MC1288”):ti,ab,kw OR (“MC-1288”):ti,ab,kw OR (“Calcitriol-Nefro”):ti,ab,kw OR (“Calcitriol Nefro”):ti,ab,kw |
| #15 | (“1,25-dihydroxy-20-epi-Vitamin D3”):ti,ab,kw OR (“1,25 dihydroxy 20 epi Vitamin D3”):ti,ab,kw OR (“D3, 1,25-dihydroxy-20-epi-Vitamin”):ti,ab,kw |
| #16 | (“1 alpha, 25-dihydroxy-20-epi-Vitamin D3”):ti,ab,kw OR (“1,25(OH)2-20epi-D3”):ti,ab,kw OR (“20-epi-1alpha,25-dihydroxycholecaliferol”):ti,ab,kw |
| #17 | (“Silkis”):ti,ab,kw OR (“Soltriol”):ti,ab,kw |
| #18 | #8 OR #9 OR #10 #11 OR #12 OR #13 #14 OR #15 OR #16 #17 |
| #19 | (“alfacalcidol”):ti,ab,kw OR (“1α-hydroxyvitamin D”):ti,ab,kw OR (“25-hydroxyvitamin D ”):ti,ab,kw OR (“calcidiol”):ti,ab,kw |
| #20 | #1 OR #4 OR #7 #18 OR #19 |
| #21 | MeSH descriptor: [Alopecia Areata] explode all trees |
| #22 | (“Alopecia Circumscripta”):ti,ab,kw |
| #23 | #21 OR #22 |
| #24 | MeSH descriptor: [Randomized controlled trial] explode all trees |
| #25 | (“Randomized controlled trial”):ti,ab,kw OR (“Randomized”):ti,ab,kw OR (“controlled”):ti,ab,kw |
| #26 | #24 OR #25 |
| #27 | #20 AND #23 AND #26 |
References
- Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol, 2018
- Alopecia areata: review of epidemiology, clinical features, pathogenesis, and new treatment options. Int J Trichology, 2018
- Alopecia areata: a comprehensive review of pathogenesis and management. Clin Rev Allergy Immunol, 2018
- Retrospective review of diphencyprone in the treatment of alopecia areata. Clin Exp Dermatol, 2016
- Safety concerns when using novel medications to treat alopecia. Expert Opin Drug Saf, 2018
- The utilization of phototherapy in the department of dermatology, Hospital Kuala Lumpur: a 5-year audit. Med J Malaysia, 2018
- Association of alopecia areata with vitamin D and calcium levels: a systematic review and meta-analysis. Dermatol Ther (Heidelb), 2020
- Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm. Int J Dermatol, 2018
- Serum vitamin D level is related to disease severity in pediatric alopecia areata. J Cosmet Dermatol, 2018
- Vitamin D and the skin: a review for dermatologists. Vitamina D y la piel. Una revisión para dermatólogos. Actas Dermosifiliogr, 2019
- Serum vitamin D level and disease severity of alopecia areata: a meta-regression analysis. J Am Acad Dermatol, 2018
- Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory [published online ahead of print, 2020 Aug 22]. JBMR Plus, 2020
- Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case-control study. Br J Dermatol, 2012
- Vitamin D supplementation ameliorates severity of major depressive disorder. J Mol Neurosci, 2020
- Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience, 2015
- Oxidative stress in alopecia areata: a systematic review and meta-analysis. Int J Dermatol, 2020
- Effects of vitamin D levels and supplementation on atopic dermatitis: a systematic review. Pediatr Dermatol, 2018
- Oral vitamin D3 supplementation for chronic plaque psoriasis: a randomized, double-blind, placebo-controlled trial. J Dermatolog Treat, 2018
- Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: a prospective study. Clin Nutr ESPEN, 2016
- Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation [published correction appears in BMJ. 2016 Jul 21;354:i4086]. BMJ, 2015
- Alopecia areata investigational assessment guidelines--part II. National alopecia areata foundation. J Am Acad Dermatol, 2004
- Untitled Dietary Reference Intakes for Calcium and Vitamin D, 2011
- Objective outcome measures: collecting meaningful data on alopecia areata. J Am Acad Dermatol, 2018
- Alopecia areata progression index, a scoring system for evaluating overall hair loss activity in alopecia areata patients with pigmented hair: a development and reliability assessment. Dermatology, 2016
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med, 2009
- The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 2011
- Untitled Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated 2011], 2011
- Dealing with missing outcome data in meta-analysis. Res Synth Methods, 2020
- Quantifying heterogeneity in a meta-analysis. Stat Med, 2002
- How to do a meta-analysis. Br J Math Stat Psychol, 2010
- Quantifying publication bias in meta-analysis. Biometrics, 2018
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