5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety.

Rachita Dhurat, Aseem Sharma, Lidia Rudnicka, George Kroumpouzos, Martin Kassir et al.

Review Dermatologic therapy 2020 60 citazioni

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Study Design

Tipo di studio: Review
Popolazione: Androgenetic alopecia patients

Intervento: 5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety. None
Comparatore: None
Esito primario: None
Direzione dell'effetto: Positive
Rischio di bias: Unclear

Abstract

Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

TL;DR

This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

Used In Evidence Reviews

A Finasteride per Alopecia androgenetica

A Dutasteride per Alopecia androgenetica

5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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