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Figure 6

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Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

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Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

Figure 5

Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.

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CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.

Figure 7

CBD-mediated TRPV1 desensitization was reversed by forskolin (cAMP pathway activator) and cyclosporin (calcineurin inhibitor), indicating that cannabidiol's analgesic mechanism involves phosphatase-dependent receptor desensitization in DRG neurons.

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Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.

Figure 8

Forskolin-stimulated cAMP levels were significantly inhibited by CBD co-treatment in DRG neurons, suggesting cannabidiol modulates the cAMP-PKA signaling axis downstream of TRPV1 activation.

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Figure 6

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Source Paper

CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.

Journal of pain research (2020)

PMID: 32982390

DOI: 10.2147/JPR.S258433

Cite This Figure

![Figure 6: Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.](https://pdfs.citedhealth.com/figures/32982390/204.png)

> Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." *Journal of pain research*, 2020. PMID: [32982390](https://pubmed.ncbi.nlm.nih.gov/32982390/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/32982390/204.png" alt="Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways." />
  <figcaption>Figure 6. Calcium imaging or electrophysiological recordings from cultured DRG neurons demonstrating CBD's dose-dependent effects on TRPV1-mediated capsaicin responses and downstream signaling pathways.<br>  Source: Uma Anand et al. "CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.." <em>Journal of pain research</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32982390/">32982390</a></figcaption>
</figure>

Evidenze correlate

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Vitamina B12 per Perdita di capelli da carenza nutrizionale

Grado F · 19 studi