What is the recommended dosage for Stinging Nettle Root?

General: 300-600 mg/day root extract (standardized)

What are the side effects of Stinging Nettle Root?

Potential side effects include: Mild gastrointestinal upset, Allergic reactions (rare — related to leaf, not root), May cause fluid retention.

Does stinging nettle root help with hair loss?

Stinging nettle root (Urtica dioica) has been studied for its potential to inhibit 5-alpha reductase and sex hormone-binding globulin (SHBG), both involved in androgenetic alopecia. It is sometimes combined with saw palmetto in hair supplement formulas. Clinical evidence for direct hair growth effects in humans is limited, though the anti-androgenic mechanism is plausible. Consult your healthcare provider.

How might stinging nettle root inhibit DHT and support hair density?

Stinging nettle root (Urtica dioica) contains lectins, polysaccharides, and sterols that may inhibit 5-alpha reductase — the enzyme responsible for converting testosterone into DHT, which miniaturizes hair follicles in androgenetic alopecia. Nettle root extracts also appear to bind sex hormone-binding globulin (SHBG), potentially altering the ratio of free androgens available to follicle receptors. In vitro and animal studies support these mechanisms, but large randomized trials specifically for hair density in humans are limited. Nettle root is often combined with saw palmetto in commercial formulas, and the combination may have additive anti-androgenic effects. Consult your healthcare provider.

Is stinging nettle root safe and are there any interactions to be aware of?

Stinging nettle root is generally well-tolerated at typical supplemental doses of 300–600 mg of standardized root extract daily. Clinical studies for related conditions (such as benign prostatic hyperplasia) using these doses over 6 months have found few serious adverse effects. However, nettle root may have mild diuretic and blood pressure-lowering properties that could interact with antihypertensives and diuretic medications. It may also interact with blood thinners and diabetes medications by influencing glucose metabolism. Pregnancy and breastfeeding are typical contraindications. Always review your medications with a healthcare provider before adding nettle root.

Stinging Nettle Root

herb

Also known as: Urtica dioica, Nettle root, Brennessel

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About

Stinging nettle root (Urtica dioica) has been studied primarily for benign prostatic hyperplasia, where it demonstrates 5-alpha-reductase and aromatase inhibition. These anti-androgenic properties have led to interest in its potential role in supporting hair health for androgenetic alopecia, though direct clinical hair loss trials are scarce.

How It Works

Lignans and polyphenols inhibit 5-alpha-reductase and aromatase; binds sex hormone-binding globulin (SHBG), potentially reducing free DHT at the follicular level.

Evidence For Conditions

Condition	Grade	Studies	Participants
Androgenetic Alopecia	D	0	--	View →
Hormonal Hair Changes (PCOS & Menopause)	D	0	--	View →

Side Effects

Mild gastrointestinal upset
Allergic reactions (rare — related to leaf, not root)
May cause fluid retention

Drug & Supplement Interactions

Anticoagulants (nettle leaf contains vitamin K; root extract has less concern)
Antihypertensives (may have additive blood pressure lowering effects)
Diabetes medications (may affect blood glucose levels)
Lithium (nettle may reduce lithium excretion)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Ashwagandha Curcumin Fenugreek Ginseng Green Tea Extract

Quick Facts

Dosage: General: 300-600 mg/day root extract (standardized)
Forms: capsule tablet liquid extract
Natural Sources: Stinging nettle root
Upper Limit: Not formally established; well tolerated at 600 mg/day in studies
Best Time: With meals to reduce gastrointestinal discomfort

Evidence Summary

Androgenetic Alopecia D

Hormonal Hair Changes (PCOS & Menopause) D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.