Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

Tomoharu Kuboyama, Chihiro Tohda, Katsuko Komatsu

Review Biological & pharmaceutical bulletin 2014 110 sitasi

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Study Design

Jenis Studi: Review

Intervensi: Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.
Pembanding: Placebo
Arah Efek: Positive
Risiko Bias: Unclear

Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

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Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

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Abstract

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