Deskripsi
Finasteride's mechanism of inhibition is depicted at the molecular level, showing covalent adduct formation between NADPH and finasteride that prevents further hydride transfer to testosterone.
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Figure 2
Classification systems for androgenetic alopecia severity are presented, distinguishing male and female pattern hair loss stages.
diagram
Figure 3
The DHT synthesis pathway via SRD5A2 is diagrammed, showing how 5-alpha reductase converts testosterone to dihydrotestosterone in the presence of NADPH, the key hormonal driver of AGA.
diagram
Figure 5
The three-dimensional structure of human SRD5A2 is shown with its seven transmembrane domains, active site, and NADP-DHF adduct positioning within the enzyme channel.
diagramCite This Figure
 > Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." *JAAD international*, 2023. PMID: [37823040](https://pubmed.ncbi.nlm.nih.gov/37823040/)
<figure> <img src="https://pdfs.citedhealth.com/figures/37823040/111.png" alt="Finasteride's mechanism of inhibition is depicted at the molecular level, showing covalent adduct formation between NADPH and finasteride that prevents further hydride transfer to testosterone." /> <figcaption>Figure 4. Finasteride's mechanism of inhibition is depicted at the molecular level, showing covalent adduct formation between NADPH and finasteride that prevents further hydride transfer to testosterone.<br> Source: Sincengile Ntshingila et al. "Androgenetic alopecia: An update.." <em>JAAD international</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37823040/">37823040</a></figcaption> </figure>