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Figure 5. Effects of a two‐week administration of CBD on intrahepatic expression of cytochrome P450s and UDP‐glucuronosyltransferases. Livers were collected 6 h after the last gavage and gene expression was measured using the quantitative real‐time (qRT)
Figure 11. Figure 5. Effects of a two‐week administration of CBD on intrahepatic expression of cytochrome P450s and UDP‐glucuronosyltransferases. Livers were collected 6 h after the last gavage and gene expression was measured using the quantitative real‐time (qRT) PCR. * ‐ indicate data analyzed by One‐Way ANOVA with Tukey’s post‐test, and # indicate non‐normal data analyzed with a Kruskal‐ Wallis and Dunn’s post‐hoc test. Data are presented as mean ± SEM fold changed from vehicle (n = 6), with * or # as p < 0.05; ** or ## as p < 0.01; *** or ### as p < 0.001; and **** or #### as p

Deskripsi

Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.

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Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.

Figure 5

Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.

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Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

Figure 6

Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

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Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

Figure 7

Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

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Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.

Figure 8

Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.

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Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

Figure 9

Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

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Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

Figure 10

Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

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Figure 11

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Source Paper

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Molecules (Basel, Switzerland) (2019)

PMID: 31052254

DOI: 10.3390/molecules24091694

Cite This Figure

![Figure 11: Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.](https://pdfs.citedhealth.com/figures/31052254/135.png)

> Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." *Molecules (Basel, Switzerland)*, 2019. PMID: [31052254](https://pubmed.ncbi.nlm.nih.gov/31052254/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/31052254/135.png" alt="Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses." />
  <figcaption>Figure 11. Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.<br>  Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." <em>Molecules (Basel, Switzerland)</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31052254/">31052254</a></figcaption>
</figure>

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