Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
Richard P Allen
Review
Sleep medicine clinics
2015
158 उद्धरण
PubMed
DOI
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Study Design
- अध्ययन प्रकार
- Review
- हस्तक्षेप
- Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
- तुलनित्र
- Placebo
- प्रभाव की दिशा
- Neutral
- पूर्वाग्रह का जोखिम
- Unclear
Abstract
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.
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