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Figure 3. Effects of 2-week administration of CBD on liver histomorphology. H&E stained liver sections from (A) vehicle mice or those gavaged with (B) 61.5 mg/kg, (C) 184.5 mg/kg, or (D) 615 mg/kg CBD in sesame oil for 2 weeks. Note that 615 mg/kg grou
Figure 8. Figure 3. Effects of 2-week administration of CBD on liver histomorphology. H&E stained liver sections from (A) vehicle mice or those gavaged with (B) 61.5 mg/kg, (C) 184.5 mg/kg, or (D) 615 mg/kg CBD in sesame oil for 2 weeks. Note that 615 mg/kg group was terminated after 2–3 doses due to overt toxicity elicited by CBD.

Description

Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.

More Figures from This Paper

Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.

Figure 5

Single gavage with CBD at 246, 738, or 2460 mg/kg produced dose-dependent hepatotoxic effects in mice. Body weight changes, liver-to-body weight ratios, and intrahepatic total glutathione concentrations at 24 hours indicate significant liver burden at the highest doses.

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Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

Figure 6

Sub-acute CBD administration (10 daily doses at 61.5-615 mg/kg) produced cumulative hepatic effects. This figure presents body weight curves and liver enzyme data from the two-week dosing protocol.

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Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

Figure 7

Single CBD gavage induced significant changes in hepatic cytochrome P450 and UDP-glucuronosyltransferase expression. Quantitative real-time PCR data demonstrate dose-dependent upregulation of these xenobiotic-metabolizing enzymes at 24 hours post-treatment.

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Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

Figure 9

Sub-acute CBD dosing produced changes in liver weight and serum biochemistry parameters. This figure compiles multi-parameter hepatotoxicity data from the 10-day dosing study.

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Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

Figure 10

Hepatic gene expression profiling after sub-acute CBD treatment reveals broader metabolic impacts. This figure presents transcriptomic data on stress-response and metabolism-related genes in the liver.

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Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.

Figure 11

Two-week CBD administration produced sustained changes in cytochrome P450 and UDP-glucuronosyltransferase gene expression. Quantitative PCR data collected 6 hours after the last gavage indicate persistent hepatic enzyme induction at higher CBD doses.

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Figure 8

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Source Paper

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Molecules (Basel, Switzerland) (2019)

PMID: 31052254

DOI: 10.3390/molecules24091694

Cite This Figure

![Figure 8: Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.](https://pdfs.citedhealth.com/figures/31052254/103.png)

> Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." *Molecules (Basel, Switzerland)*, 2019. PMID: [31052254](https://pubmed.ncbi.nlm.nih.gov/31052254/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/31052254/103.png" alt="Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups." />
  <figcaption>Figure 8. Hematoxylin and eosin-stained liver sections reveal dose-dependent histomorphological changes after 2-week CBD administration. Mice receiving 615 mg/kg CBD exhibited notable hepatocellular alterations compared to vehicle controls and lower-dose groups.<br>  Source: Laura E Ewing et al. "Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.." <em>Molecules (Basel, Switzerland)</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31052254/">31052254</a></figcaption>
</figure>

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