Effects of platelet-rich plasma application on hair follicle count, telogen/anagen ratio, and miniaturized hair ratio in patients with androgenic alopecia: alone or in combination with other treatments.

OBJECTIVE: Androgenic alopecia (AGA) is a genetic, non-scarring hair loss disorder influenced by peripheral androgens, affecting patients' appearance, and quality of life. This study compared the effects of 5% minoxidil, platelet-rich plasma (PRP), and their combination on hair count, telogen/anagen ratio, and vellus hair in AGA patients. MATERIAL AND METHODS: This retrospective study included AGA patients treated at the dermatology department. Dermoscopic images taken before and 6 months after treatment with the Molemax device were analyzed using Tricoscan software. Demographic data, disease characteristics, and previous treatments were recorded. Staging followed the Ludwig and Hamilton-Norwood classifications. Patients were categorized into three groups: Group I (5% minoxidil), Group II (PRP), and Group III (combined therapy). RESULTS: The study included 45 patients (53.3% female; mean age 27.8 ± 8.6 years). Groups II and III showed significant improvement in hair count, density, terminal hair count, and anagen ratio (p < 0.05). Vellus hair count and density significantly decreased in Group III (p < 0.05). Patient-reported improvement did not differ significantly among groups (p > 0.05). CONCLUSION: PRP improves hair growth parameters in AGA and is more effective when combined with minoxidil, especially in reducing vellus hair. These results support PRP's role in AGA treatment.