[Spironolactone in dermatological treatment. On and off label indications].

C M Salavastru, K Fritz, G S Tiplica

Other Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 2013 19 Zitierungen

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Study Design

Studientyp: Review
Population: Women with androgen-related dermatologic conditions

Intervention: [Spironolactone in dermatological treatment. On and off label indications]. 50-100 mg daily
Vergleichsgruppe: None
Primärer Endpunkt: Female acne, FPHL, hirsutism (off-label dermatology uses)
Wirkungsrichtung: Positive
Verzerrungsrisiko: Unclear

Abstract

There are no currently FDA/EMEA-approved dermatologic indications for spironolactone and its off-label uses are, among others, female acne, female pattern hair loss, hidradenitis suppurativa or hirsutism. The rationale behind these relays on the mechanism of action of spironolactone which interferes with the hormone-controlled sebum and sweat gland secretion and with androgen stimulated hair growth. The average dose used by the dermatologits is 50-100 mg daily. It should not be used in pregnant and lactating women and it is not used in men due to the risk of feminization. Although further studies to assess its efficacy and safety are necessary, currently spironolactone is regarded as a useful tool in the dermatologic treatment armamentarium.

Zusammenfassung

Spironolactone is regarded as a useful tool in the dermatologic treatment armamentarium and should not be used in pregnant and lactating women and it is not used in men due to the risk of feminization.

Used In Evidence Reviews

A Spironolacton für Weiblicher Haarausfall

[Spironolactone in dermatological treatment. On and off label indications].

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Study Design

Abstract

Zusammenfassung

Used In Evidence Reviews

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